Association between interleukin-6 rs1800795 polymorphism and the decreased risk of type 2 diabetes mellitus: an updated meta-analysis

It has been reported that the single nucleotide polymorphism (SNP) rs1800795 in interleukin-6 (IL-6) gene is associated with the susceptibility to type 2 diabetes mellitus (T2DM). However, the conclusions in several recent reports remained controversial. Herein, we performed this meta-analysis to investigate the relationship of rs1800795 and T2DM risk. A systematic search of relevant literatures was conducted through the databases of PubMed, Embase, and CBMdisc up to December 2016. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between rs1800795 and T2DM risk in four genetic models. Twelve case-control studies were included in the final meta-analysis. Overall, our results showed that rs1800795 was associated with the decreased risk of T2DM in allelic and recessive models, but not dominant or addictive models. No obvious published bias was found in any models for the SNP. In conclusion, the current meta-analysis demonstrated that the SNP of IL-6 gene was correlated with the decreased risk of T2DM. However, studies including a larger number of subjects with more detailed individual information are needed for further validation of our conclusion.