Microwave-assisted synthesis and evaluation of antibacterial activity of novel 6-fluoroaryl-[1,2,4]triazolo[1,5-a]pyrimidines

被引：5

作者：

Verbitskiy, Egor V. ^{[1
,2
]}

Baskakova, Svetlana A. ^{[1
]}

Rasputin, Nikolay A. ^{[1
]}

Gerasimova, Natal'ya A. ^{[3
]}

Amineva, Polina G. ^{[3
]}

Evstigneeva, Natal'ya P. ^{[3
]}

Zil'berberg, Natal'ya V. ^{[3
]}

Kungurov, Nikolay V. ^{[3
]}

Kravchenko, Marionella A. ^{[4
]}

Skornyakov, Sergey N. ^{[4
]}

Rusinov, Gennady L. ^{[1
,2
]}

Chupakhin, Oleg N. ^{[1
,2
]}

Charushin, Valery N. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Postovsky Inst Organ Synth, Ural Branch, S Kovalevskoy Str 22, Ekaterinburg 620990, Russia

[2] Ural Fed Univ, Mira St 19, Ekaterinburg 620002, Russia

[3] Ural Res Inst Dermatol Venereol & Immunopathol, Scherbakova St 8, Ekaterinburg 620076, Russia

[4] Ural Res Inst Phthisiopulmonol, 22 Partsezda St 50, Ekaterinburg 620039, Russia

来源：

ARKIVOC | 2016年

基金：

俄罗斯科学基金会;

关键词：

1,2,4]triazolo[1,5-a]pyrimidines; Suzuki cross-coupling; microwave irradiation; antimycobacterial activity; anti-gonorrhea activity; AGENTS; INHIBITORS; DESIGN; S-N(H);

D O I：

10.3998/ark.5550190.p009.731

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

using the microwave-assisted Suzuki cross-coupling reaction from readily available 6-bromo-[ 1,2,4] triazolo[1,5-a] pyrimidine. The antimicrobial activity of new compounds has been evaluated in vitro against Mycobacterium tuberculosis H(37)Rv and gram-negative (Neisseria gonorrhoeae ATCC 49226) bacteria.

引用

页码：268 / 278

页数：11

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