Novel probiotics and prebiotics: road to the market

被引：108

作者：

Kumar, Himanshu ^{[1
]}

Salminen, Seppo ^{[1
]}

Verhagen, Hans ^{[2
,3
]}

Rowland, Ian ^{[4
]}

Heimbach, Jim ^{[5
,6
]}

Banares, Silvia ^{[7
]}

Young, Tony ^{[8
]}

Nomoto, Koji ^{[9
]}

Lalonde, Melanie ^{[10
]}

机构：

[1] Univ Turku, Funct Foods Forum, FIN-20520 Turku, Finland

[2] Natl Inst Publ Hlth & Environm RIVM, NL-3720 BA Bilthoven, Netherlands

[3] Univ Ulster, Coleraine BT52 1SA, Londonderry, North Ireland

[4] Univ Reading, Reading RG6 6AP, Berks, England

[5] JHeimbach LLC, Port Royal, VA 22535 USA

[6] Dairy & Food Culture Technol, Centennial, CO 80122 USA

[7] Abad Oliba CEU Univ, Barcelona 08022, Spain

[8] Kleinfeld, Kaplan & Becker LLP, Washington, DC USA

[9] Yakult Cent Inst, Kunitachi, Tokyo 1868650, Japan

[10] BioK Plus Int Inc, Laval, PQ H7V 4B3, Canada

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2015年 / 32卷

关键词：

Biotechnology;

D O I：

10.1016/j.copbio.2014.11.021

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel probiotics and prebiotics designed to manipulate the gut microbiota for improving health outcomes are in demand as the importance of the gut microbiota in human health is revealed. The regulations governing introduction of novel probiotics and prebiotics vary by geographical region. Novel foods and foods with health claims fall under specific regulations in several countries. The paper reviews the main requirements of the regulations in the EU, USA, Canada and Japan. We propose a number of areas that need to be addressed in any safety assessment of novel probiotics and prebiotics. These include publication of the genomic sequence, antibiotic resistance profiling, selection of appropriate in vivo model, toxicological studies (including toxin production) and definition of target population.

引用

页码：99 / 103

页数：5

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