Non-alcoholic fatty liver disease (NAFLD) covers a spectrum of lesions ranging from steatosis (Non-alcoholic Fatty Liver or NAFL) to a complex pattern with hepatocellular injury and inflammation (non-alcoholic steatohepatitis; NASH) in the absence of alcohol intake. However, it is increasingly clear that intermediate patterns may exist. The histopathological evaluation of liver biopsy samples is central in the diagnosis of NAFLD and NASH in the absence of sufficiently accurate non-invasive tests because a precise definition of each group is a key issue. When at least 5% of hepatocytes display steatosis, patients can be defined as having NAFLD in an appropriate clinical context. When, in addition, lobular inflammation and liver cell clarification/ballooning are present, then the lesion is usually defined as NASH. Evaluation of the stage of fibrosis is even more fundamental than necroinflammation since it is the main prognostic factor of this disease. Semi-quantitative histological scoring systems have been proposed for NAFLD, but they are not useful in clinical practice and each has certain limitations. For comprehensive purposes, we suggest describing histopathological lesions in NAFLD using the SAF (Steatosis, Activity, Fibrosis) score which assesses separately the grade of steatosis (5, from SO to 53), the grade of activity (A from AO to A4 by adding grades of ballooning and lobular inflammation, both from 0 to 2) and the stage of fibrosis (F from FO to F4).
机构:
Univ Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USAUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Angulo, Paul
;
Kleiner, David E.
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Natl Canc Inst, Pathol Lab, Bethesda, MD 20892 USAUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Kleiner, David E.
;
Dam-Larsen, Sanne
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Koege Univ Hosp, Dept Med, Koege, DenmarkUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Dam-Larsen, Sanne
;
Adams, Leon A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6009, AustraliaUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Adams, Leon A.
;
Bjornsson, Einar S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iceland, Natl Univ Hosp, Fac Med, Sect Gastroenterol & Hepatol, Reykjavik, IcelandUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Bjornsson, Einar S.
;
Charatcharoenwitthaya, Phunchai
论文数: 0引用数: 0
h-index: 0
机构:
Mahidol Univ, Siriraj Hosp, Fac Med, Bangkok 10700, ThailandUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Charatcharoenwitthaya, Phunchai
;
Mills, Peter R.
论文数: 0引用数: 0
h-index: 0
机构:
Gartnavel Royal Hosp, Glasgow, Lanark, ScotlandUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Mills, Peter R.
;
Keach, Jill C.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USAUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Keach, Jill C.
;
Lafferty, Heather D.
论文数: 0引用数: 0
h-index: 0
机构:
Gartnavel Royal Hosp, Glasgow, Lanark, ScotlandUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Lafferty, Heather D.
;
Stahler, Alisha
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USAUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Stahler, Alisha
;
Haflidadottir, Svanhildur
论文数: 0引用数: 0
h-index: 0
机构:
Oslo Univ Hosp, Rikshosp, Dept Pediat, Oslo, NorwayUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
机构:
Hop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Univ Paris Diderot, Ctr Rech Bichat Beaujon, INSERM, U773, Paris, FranceHop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Bedossa, Pierre
;
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Poitou, Christine
;
Veyrie, Nicolas
论文数: 0引用数: 0
h-index: 0
机构:
Hop Ambroise Pare, Assistance Publ Hop Paris, Dept Surg, Boulogne, FranceHop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Veyrie, Nicolas
;
Bouillot, Jean-Luc
论文数: 0引用数: 0
h-index: 0
机构:
Hop Ambroise Pare, Assistance Publ Hop Paris, Dept Surg, Boulogne, FranceHop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Bouillot, Jean-Luc
;
Basdevant, Arnaud
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, Assistance Publ Hop Paris, ICAN, Paris, France
INSERM, U872, Paris, France
Univ Paris 06, Ctr Rech Cordeliers, UMR S 872, Paris, FranceHop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Basdevant, Arnaud
;
Paradis, Valerie
论文数: 0引用数: 0
h-index: 0
机构:
Hop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Univ Paris Diderot, Ctr Rech Bichat Beaujon, INSERM, U773, Paris, FranceHop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Paradis, Valerie
;
Tordjman, Joan
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, Assistance Publ Hop Paris, ICAN, Paris, France
INSERM, U872, Paris, France
Univ Paris 06, Ctr Rech Cordeliers, UMR S 872, Paris, FranceHop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Tordjman, Joan
;
Clement, Karine
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, Assistance Publ Hop Paris, ICAN, Paris, France
INSERM, U872, Paris, France
Univ Paris 06, Ctr Rech Cordeliers, UMR S 872, Paris, FranceHop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
机构:
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
Brunt, Elizabeth M.
;
Kleiner, David E.
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Dept Lab Med, Washington, DC USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
Kleiner, David E.
;
Wilson, Laura A.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
Wilson, Laura A.
;
Belt, Patricia
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
Belt, Patricia
;
Neuschwander-Tetri, Brent A.
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Dept Med, Div Gastroenterol & Hepatol, St Louis, MO 63103 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
机构:
Indiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
Chalasani, Naga
;
Younossi, Zobair
论文数: 0引用数: 0
h-index: 0
机构:
Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA USA
Inova Fairfax Hosp, Dept Med, Falls Church, VA USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
Younossi, Zobair
;
Lavine, Joel E.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, New York, NY USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
Lavine, Joel E.
;
Diehl, Anna Mae
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Durham, NC USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
Diehl, Anna Mae
;
Brunt, Elizabeth M.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, St Louis, MO USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
Brunt, Elizabeth M.
;
Cusi, Kenneth
论文数: 0引用数: 0
h-index: 0
机构:
Univ Florida, Gainesville, FL USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
Cusi, Kenneth
;
Charlton, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Rochester, MN USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
Charlton, Michael
;
Sanyal, Arun J.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Richmond, VA USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
机构:
Univ Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USAUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Angulo, Paul
;
Kleiner, David E.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Inst, Pathol Lab, Bethesda, MD 20892 USAUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Kleiner, David E.
;
Dam-Larsen, Sanne
论文数: 0引用数: 0
h-index: 0
机构:
Koege Univ Hosp, Dept Med, Koege, DenmarkUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Dam-Larsen, Sanne
;
Adams, Leon A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6009, AustraliaUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Adams, Leon A.
;
Bjornsson, Einar S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iceland, Natl Univ Hosp, Fac Med, Sect Gastroenterol & Hepatol, Reykjavik, IcelandUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Bjornsson, Einar S.
;
Charatcharoenwitthaya, Phunchai
论文数: 0引用数: 0
h-index: 0
机构:
Mahidol Univ, Siriraj Hosp, Fac Med, Bangkok 10700, ThailandUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Charatcharoenwitthaya, Phunchai
;
Mills, Peter R.
论文数: 0引用数: 0
h-index: 0
机构:
Gartnavel Royal Hosp, Glasgow, Lanark, ScotlandUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Mills, Peter R.
;
Keach, Jill C.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USAUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Keach, Jill C.
;
Lafferty, Heather D.
论文数: 0引用数: 0
h-index: 0
机构:
Gartnavel Royal Hosp, Glasgow, Lanark, ScotlandUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Lafferty, Heather D.
;
Stahler, Alisha
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USAUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
Stahler, Alisha
;
Haflidadottir, Svanhildur
论文数: 0引用数: 0
h-index: 0
机构:
Oslo Univ Hosp, Rikshosp, Dept Pediat, Oslo, NorwayUniv Kentucky, Med Ctr, Div Digest Dis & Nutr, Lexington, KY USA
机构:
Hop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Univ Paris Diderot, Ctr Rech Bichat Beaujon, INSERM, U773, Paris, FranceHop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Bedossa, Pierre
;
论文数: 引用数:
h-index:
机构:
Poitou, Christine
;
Veyrie, Nicolas
论文数: 0引用数: 0
h-index: 0
机构:
Hop Ambroise Pare, Assistance Publ Hop Paris, Dept Surg, Boulogne, FranceHop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Veyrie, Nicolas
;
Bouillot, Jean-Luc
论文数: 0引用数: 0
h-index: 0
机构:
Hop Ambroise Pare, Assistance Publ Hop Paris, Dept Surg, Boulogne, FranceHop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Bouillot, Jean-Luc
;
Basdevant, Arnaud
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, Assistance Publ Hop Paris, ICAN, Paris, France
INSERM, U872, Paris, France
Univ Paris 06, Ctr Rech Cordeliers, UMR S 872, Paris, FranceHop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Basdevant, Arnaud
;
Paradis, Valerie
论文数: 0引用数: 0
h-index: 0
机构:
Hop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Univ Paris Diderot, Ctr Rech Bichat Beaujon, INSERM, U773, Paris, FranceHop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Paradis, Valerie
;
Tordjman, Joan
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, Assistance Publ Hop Paris, ICAN, Paris, France
INSERM, U872, Paris, France
Univ Paris 06, Ctr Rech Cordeliers, UMR S 872, Paris, FranceHop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
Tordjman, Joan
;
Clement, Karine
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, Assistance Publ Hop Paris, ICAN, Paris, France
INSERM, U872, Paris, France
Univ Paris 06, Ctr Rech Cordeliers, UMR S 872, Paris, FranceHop Beaujon, Assistance Publ Hop Paris, Dept Pathol, F-92100 Clichy, France
机构:
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
Brunt, Elizabeth M.
;
Kleiner, David E.
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Dept Lab Med, Washington, DC USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
Kleiner, David E.
;
Wilson, Laura A.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
Wilson, Laura A.
;
Belt, Patricia
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
Belt, Patricia
;
Neuschwander-Tetri, Brent A.
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Dept Med, Div Gastroenterol & Hepatol, St Louis, MO 63103 USAWashington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
机构:
Indiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
Chalasani, Naga
;
Younossi, Zobair
论文数: 0引用数: 0
h-index: 0
机构:
Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA USA
Inova Fairfax Hosp, Dept Med, Falls Church, VA USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
Younossi, Zobair
;
Lavine, Joel E.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, New York, NY USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
Lavine, Joel E.
;
Diehl, Anna Mae
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Durham, NC USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
Diehl, Anna Mae
;
Brunt, Elizabeth M.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, St Louis, MO USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
Brunt, Elizabeth M.
;
Cusi, Kenneth
论文数: 0引用数: 0
h-index: 0
机构:
Univ Florida, Gainesville, FL USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
Cusi, Kenneth
;
Charlton, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Rochester, MN USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
Charlton, Michael
;
Sanyal, Arun J.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Richmond, VA USAIndiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA