Renal ischemia-reperfusion injury:: an inescapable event affecting kidney transplantation outcome

被引:11
作者
Böhmová, R
Viklicky, O [1 ]
机构
[1] Inst Clin & Expt Med, Dept Clin Immunol, Transplant Ctr, Prague 14000, Czech Republic
[2] Inst Clin & Expt Med, Dept Nephrol, Transplant Ctr, Prague 14000, Czech Republic
关键词
D O I
10.1007/BF02815613
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Ischemia-reperfusion (I-R) injury has been shown to be a common cause of late and irreversible complications during a variety of standard medical and surgical procedures. The pathogenesis of events which follow the I-R involves both injured endothelium and activated leukocytes and their interaction In kidney transplantation. an I-R injury occurs in situations such as graft harvesting, cold storage and surgery. Clinical consequences of I-R injury have been considered to be delayed graft function and acute rejection in the short term and chronic rejection late after transplantation, Here we focused on current knowledge of pathophysiology of renal I-R injury in kidney transplantation and on possibilities of experimental therapy.
引用
收藏
页码:267 / 276
页数:10
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