Nano-carrier based drug delivery systems for sustained antimicrobial agent release from orthopaedic cementous material

被引：45

作者：

Al Thaher, Yazan ^{[1
]}

Perni, Stefano ^{[1
]}

Prokopovich, Polina ^{[1
]}

机构：

[1] Cardiff Univ, Sch Pharm & Pharmaceut Sci, Redwood Bldg,King Edward VII Ave, Cardiff CF10 3NB, S Glam, Wales

来源：

ADVANCES IN COLLOID AND INTERFACE SCIENCE | 2017年 / 249卷

关键词：

PMMA; Nanotechnology; Bone cement; Nanoparticles; Antimicrobial; TJR; PJI; TOTAL KNEE ARTHROPLASTY; ACRYLIC BONE-CEMENT; CALCIUM-PHOSPHATE CEMENTS; TOTAL HIP-ARTHROPLASTY; ANTIBIOTIC-IMPREGNATED CEMENT; GLASS POLYALKENOATE CEMENTS; PROSTHETIC JOINT INFECTION; REVISION TOTAL KNEE; 55 YEARS OLD; 2-STAGE REVISION;

D O I：

10.1016/j.cis.2017.04.017

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Total joint replacement (TJR), such as hip and knee replacement, is a popular procedure worldwide. Prosthetic joint infections (PJI) after this procedure have been widely reported, where treatment of such infections is complex with high cost and prolonged hospital stay. In cemented arthroplasties, the use of antibiotic loaded bone cement (ALBC) is a standard practice for the prophylaxis and treatment of PJI. Recently, the development of bacterial resistance by pathogenic microorganisms against most commonly used antibiotics increased the interest in alternative approaches for antimicrobial delivery systems such as nanotechnology. This review summarizes the efforts made to improve the antimicrobial properties of PMMA bone cements using nanotechnology based antibiotic and non-antibiotic delivery systems to overcome drawbacks of ALBC in the prophylaxis and treatment of PJIs after hip and knee replacement.

引用

页码：234 / 247

页数：14

共 181 条

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