Highly stereoselective synthesis of anti-N-protected-α-amino epoxides

被引：44

作者：

Hoffman, RV ^{[1
]}

Weiner, WS ^{[1
]}

Maslouh, N ^{[1
]}

机构：

[1] New Mexico State Univ, Dept Chem & Biochem, Las Cruces, NM 88003 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 17期

关键词：

D O I：

10.1021/jo010319h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient method for the synthesis of anti-N-protected amino epoxides from carbamate-protected amino acids is described. The two key steps are the monobromination of a beta -ketoester and chelation-controlled reduction of a bromomethyl ketone intermediate. Good overall yields, high diastereoselectivity, and excellent functional group compatibility are characteristic.

引用

页码：5790 / 5795

页数：6

共 31 条

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