Homeobox genes in normal and malignant cells

被引：227
作者：
Cillo, C
Cantile, M
Faiella, A
Boncinelli, E
机构：
[1] Univ Naples Federico II, Sch Med, Dept Clin & Expt Med, I-80131 Naples, Italy
[2] Ist Sci H San Raffaele, Dept Biotechnol, DIBIT, Milan, Italy
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2001年 / 188卷 / 02期
关键词：
D O I：
10.1002/jcp.1115
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Homeobox genes are transcription factors primarily involved in embryonic development. Several homeobox gene families have so far been identified: Hox, EMX, PAX, MSX as well as many isolated divergent homeobox genes. Among these, Hox genes are most intriguing for having a regulatory network structure organization. Recent indications suggest the involvement of homeobox genes in (i) crucial adult eukariotic cell functions and (ii) human diseases, spanning from diabetes to cancer. In this review we will discuss the mechanisms through which homeobox genes act, and will propose a model for the function of the Hox gene network as decoding system for achieving specific genetic programs. New technologies for whole-genome RNA expression will be crucial to evaluate the clinical relevance of homeobox genes in structural and metabolic diseases. J. Cell. Physiol. 188: 161-169, 2001. (C) 2001 Wiley-Liss, Inc.
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页码：161 / 169
页数：9
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