microRNAs in neurons: manifold regulatory roles at the synapse

被引：142
作者：
Siegel, Gabriele
Saba, Reuben
Schratt, Gerhard [1 ]
机构：
[1] Univ Heidelberg, Interdisziplinares Zentrum Neurowissensch, Jr Grp SFB488, Heidelberg, Germany
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2011年 / 21卷 / 04期
关键词：
MENTAL-RETARDATION PROTEIN; FRAGILE-X-SYNDROME; NEWBORN NEURONS; MOUSE MODEL; PLASTICITY; PATHWAY; MEMORY; MORPHOGENESIS; DICER; BRAIN;
D O I：
10.1016/j.gde.2011.04.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The regulation of synapse formation and plasticity in the developing and adult brain underlies a complex interplay of intrinsic genetic programs and extrinsic factors. Recent research identified microRNAs (miRNAs), a class of small non-coding RNAs, as a new functional layer in this regulatory network. Within only a few years, a network of synaptic miRNAs and their target genes has been extensively characterized, highlighting the importance of this mechanism for synapse development and physiology. Very recent data further provide insight into activity-dependent regulation of miRNAs, thereby connecting miRNAs with adaptive processes of neural circuits. First direct links between miRNA dysfunction and synaptic pathologies are emerging, raising the interest in these molecules as potential biomarkers and therapeutic targets in neurological disorders.
引用
收藏
页码：491 / 497
页数：7
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