Lipid Nanoparticles for the Posterior Eye Segment

被引：53

作者：

Bonilla, Lorena ^{[1
,2
]}

Espina, Marta ^{[1
,2
]}

Severino, Patricia ^{[3
]}

Cano, Amanda ^{[1
,2
,4
]}

Ettcheto, Miren ^{[4
,5
]}

Camins, Antoni ^{[4
,5
]}

Garcia, Maria Luisa ^{[1
,2
,5
]}

Souto, Eliana B. ^{[6
]}

Sanchez-Lopez, Elena ^{[1
,2
,4
]}

机构：

[1] Univ Barcelona, Fac Pharm, Dept Pharm Pharmaceut Technol & Phys Chem, Barcelona 08028, Spain

[2] Univ Barcelona, Inst Nanosci & Nanotechnol IN2UB, Barcelona 08028, Spain

[3] Univ Tiradentes UNIT, Ind Biotechnol Program, Ave Murilo Dantas 300, BR-49032490 Aracaju, Brazil

[4] Univ Barcelona, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona 08028, Spain

[5] Univ Barcelona, Fac Pharm & Food Sci, Dept Pharmacol Toxicol & Therapeut Chem, Barcelona 08028, Spain

[6] Univ Minho, CEB Ctr Biol Engn, Campus Gualtar, P-4710057 Braga, Portugal

来源：

PHARMACEUTICS | 2022年 / 14卷 / 01期

关键词：

ocular drug delivery; ocular barriers; lipid nanoparticles; posterior segment; drug transport; NLC; SLN; DRUG-DELIVERY SYSTEMS; OCULAR DELIVERY; IN-VITRO; DIABETIC-RETINOPATHY; OPHTHALMIC DELIVERY; SUSTAINED-RELEASE; MITOMYCIN-C; CARRIERS; CHITOSAN; OPTIMIZATION;

D O I：

10.3390/pharmaceutics14010090

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior segment will be summarized. Moreover, preparation methods and different types and subtypes of lipid nanoparticles will also be reviewed. Lipid nanoparticles used as carriers to deliver drugs to the posterior eye segment as well as their administration routes, pharmaceutical forms and ocular distribution will be discussed emphasizing the different targeting strategies most recently employed for ocular drug delivery.

引用

页数：30

共 159 条

[1]

Abd A.J., 2018, Drug Delivery for the Retina and Posterior Segment Disease, P195

[2]

Agarwal P, 2018, PHARM NANOTECHNO, P137, DOI 10.1016/B978-0-12-813667-6.00004-8

[3] Optimization by design of etoposide loaded solid lipid nanoparticles for ocular delivery: Characterization, pharmacokinetic and deposition study [J].