Remodeling of Sphingolipids by Plasma Membrane Associated Enzymes

被引：27

作者：

Aureli, Massimo ^{[2
]}

Loberto, Nicoletta ^{[2
]}

Chigorno, Vanna ^{[2
]}

Prinetti, Alessandro ^{[2
]}

Sonnino, Sandro ^{[1
,2
]}

机构：

[1] Dipartimento Chim Biochim & Biotecnol Med, I-20090 Milan, Italy

[2] Univ Milan, Ctr Excellence Neurodegenerat Dis, Dept Med Chem Biochem & Biotechnol, Segrate, Italy

来源：

NEUROCHEMICAL RESEARCH | 2011年 / 36卷 / 09期

关键词：

Sphingolipids; Hydrolases; Glycosyltranferases; Sphingomyelin synthase; Plasma membrane; Lipid rafts; CEREBELLAR GRANULE CELLS; GANGLIOSIDE-SIALIDASE; NEUTRAL SPHINGOMYELINASE-2; BETA-GALACTOSIDASE; GROWTH-CONTROL; GM3; SYNTHASE; LIPID RAFTS; BRAIN; EXPRESSION; CERAMIDE;

D O I：

10.1007/s11064-010-0360-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sphingolipid plasma membrane content and pattern is the result of several processes, among which the main, in term of quantity, are: neo-biosynthesis in endoplasmic reticulum and Golgi apparatus, membrane turnover with final catabolism in lysosomes and membrane shedding. In addition to this, past and recent data suggest that the head group of sphingolipids can be opportunely modified at the plasma membrane level, probably inside specific membrane lipid domains, by the action of enzymes involved in the sphingolipids metabolism, working directly at the cell surface. The number of membrane enzymes, hydrolases and transferases, acting on membrane sphingolipids is growing very rapidly. In this report we describe some properties of these enzymes.

引用

页码：1636 / 1644

页数：9

共 94 条

[1] Cell surface sphingolipid glycohydrolases in neuronal differentiation and aging in culture [J].