A Heat-Shock Protein Co-Inducer Treatment Improves Behavioral Performance in Rats Exposed to Hypoxia

被引：0
|
作者：
Xu, Kui [1 ,2 ]
Sun, Xiaoyan [1 ,2 ]
Erokwu, Bernadette O. [3 ]
Cernak, Ibolja [4 ]
LaManna, Joseph C. [1 ,2 ]
机构：
[1] Case Western Reserve Univ, Dept Physiol, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Biophys, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Dept Anat, Cleveland, OH 44106 USA
[4] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20773 USA
来源：
OXYGEN TRANSPORT TO TISSUE XXXII | 2011年 / 701卷
关键词：
BLOOD-FLOW; ADAPTATION; RESISTANCE;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We investigated the effect of a heat-shock protein co-inducer, arimoclomol (CytRx, LA, CA), on hypoxia-adaptive responses using a rat model of simulated altitude exposure (hypobaric hypoxia). Cognitive function was measured using a T-maze and an object recognition test. Motor function was measured using an inclined-screen test and an adhesion removal test. Immunohistochemical analyses were assessed in brain for heat-shock protein 70 (HSP 70), intercellular adhesion molecule 1 (ICAM-1) and apoptosis (TUNEL staining). Results show that both cognitive and motor performances were improved in rats treated with arimoclomol during hypoxic exposure; the hypoxia-induced expression of HSP70 and ICAM-1, and TUNEL-positive cells were reduced in brain with the treatment. Our data suggest that the arimoclomol treatment reduces the hypoxia-induced stress in brain tissue, and also improves the behavioral performance in rats during hypoxic adaptation.
引用
收藏
页码：313 / 318
页数：6
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