Tumor treating fields therapy is feasible and safe in a 3-year-old patient with diffuse midline glioma H3K27M-a case report

被引：8

作者：

Goett, Hanna ^{[1
]}

Kiez, Silke ^{[2
]}

Dohmen, Hildegard ^{[3
]}

Kolodziej, Malgorzata ^{[1
]}

Stein, Marco ^{[1
]}

机构：

[1] Univ Hosp Giessen, Dept Neurosurg, Giessen, Germany

[2] Univ Hosp Regensburg, Dept Pediat Hematooncol, Regensburg, Germany

[3] Univ Hosp Giessen, Inst Neuropathol, Giessen, Germany

来源：

CHILDS NERVOUS SYSTEM | 2022年 / 38卷 / 09期

关键词：

Glioblastoma; Glioma; Diffuse midline glioma; TTFields; Pediatric glioma; PEDIATRIC HIGH-GRADE; TTFIELDS; BRAIN; MUTATIONS; SUBGROUPS; H3F3A;

D O I：

10.1007/s00381-022-05465-z

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Since high grade gliomas are aggressive brain tumors, intensive search for new treatment options is ongoing. For adult patients with newly diagnosed (ndGBM) and recurrent glioblastoma (rGBM), low intensity intermediate frequency alternating electric fields, known as tumor treating fields (TTFields) have been established as a new treatment modality. Tumor treating fields significantly increase survival rates in combination with adjuvant temozolomide (TMZ) in adult and GBM patients. Here, we report about feasibility and safety of treatment on a pediatric patient with diffuse midline glioma who is receiving TTFields therapy in combination with temozolomide.

引用

页码：1791 / 1796

页数：6

共 22 条

[1]

Branter J, 2017, NEURO-ONCOLOGY, V19, P195

[2] DNA methylation-based classification of central nervous system tumours [J].

Capper, David ;

Jones, David T. W. ;

Sill, Martin ;

Hovestadt, Volker ;

Schrimpf, Daniel ;

Sturm, Dominik ;

Koelsche, Christian ;

Sahm, Felix ;

Chavez, Lukas ;

Reuss, David E. ;

Kratz, Annekathrin ;

Wefers, Annika K. ;

Huang, Kristin ;

Pajtler, Kristian W. ;

Schweizer, Leonille ;

Stichel, Damian ;

Olar, Adriana ;

Engel, Nils W. ;

Lindenberg, Kerstin ;

Harter, Patrick N. ;

Braczynski, Anne K. ;

Plate, Karl H. ;

Dohmen, Hildegard ;

Garvalov, Boyan K. ;

Coras, Roland ;

Hoelsken, Annett ;

Hewer, Ekkehard ;

Bewerunge-Hudler, Melanie ;

Schick, Matthias ;

Fischer, Roger ;

Beschorner, Rudi ;

Schittenhelm, Jens ;

Staszewski, Ori ;

Wani, Khalida ;

Varlet, Pascale ;

Pages, Melanie ;

Temming, Petra ;

Lohmann, Dietmar ;

Selt, Florian ;

Witt, Hendrik ;

Milde, Till ;

Witt, Olaf ;

Aronica, Eleonora ;

Giangaspero, Felice ;

Rushing, Elisabeth ;

Scheurlen, Wolfram ;

Geisenberger, Christoph ;

Rodriguez, Fausto J. ;

Becker, Albert ;

Preusser, Matthias .

NATURE, 2018, 555 (7697) :469-+

[3] Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes [J].

Castel, David ;

Philippe, Cathy ;

Calmon, Raphael ;

Le Dret, Ludivine ;

Truffaux, Nathalene ;

Boddaert, Nathalie ;

Pages, Melanie ;

Taylor, Kathryn R. ;

Saulnier, Patrick ;

Lacroix, Ludovic ;

Mackay, Alan ;

Jones, Chris ;

Sainte-Rose, Christian ;

Blauwblomme, Thomas ;

Andreiuolo, Felipe ;

Puget, Stephanie ;

Grill, Jacques ;

Varlet, Pascale ;

Debily, Marie-Anne .

ACTA NEUROPATHOLOGICA, 2015, 130 (06) :815-827

[4]

Crawford J, 2016, NEURO-ONCOLOGY, V18, P139

[5] Tumor treating fields (TTFields) delay DNA damage repair following radiation treatment of glioma cells [J].

Giladi, Moshe ;

Munster, Mijal ;

Schneiderman, Rosa S. ;

Voloshin, Tali ;

Porat, Yaara ;

Blat, Roni ;

Zielinska-Chomej, Katarzyna ;

Haag, Petra ;

Bomzon, Ze'ev ;

Kirson, Eilon D. ;

Weinberg, Uri ;

Viktorsson, Kristina ;

Lewensohn, Rolf ;

Palti, Yoram .

RADIATION ONCOLOGY, 2017, 12

[6] Mitotic Spindle Disruption by Alternating Electric Fields Leads to Improper Chromosome Segregation and Mitotic Catastrophe in Cancer Cells [J].

Giladi, Moshe ;

Schneiderman, Rosa S. ;

Voloshin, Tali ;

Porat, Yaara ;

Munster, Mijal ;

Blat, Roni ;

Sherbo, Shay ;

Bomzon, Zeev ;

Urman, Noa ;

Itzhaki, Aviran ;

Cahal, Shay ;

Shteingauz, Anna ;

Chaudhry, Aafia ;

Kirson, Eilon D. ;

Weinberg, Uri ;

Palti, Yoram .

SCIENTIFIC REPORTS, 2015, 5

[7] Tumor treating fields in pediatric high-grade glioma [J].

Green, Adam L. ;

Levy, Jean M. Mulcahy ;

Vibhakar, Rajeev ;

Hemenway, Molly ;

Madden, Jennifer ;

Foreman, Nicholas ;

Dorris, Kathleen .

CHILDS NERVOUS SYSTEM, 2017, 33 (07) :1043-1045

[8]

Hanson D, 2018, NEURO-ONCOLOGY, V20, pvi202

[9]

Kinzel A, 2018, NEURO-ONCOLOGY, V20, P225

[10] Disruption of cancer cell replication by alternating electric fields [J].

Kirson, ED ;

Gurvich, Z ;

Schneiderman, R ;

Dekel, E ;

Itzhaki, A ;

Wasserman, Y ;

Schatzberger, R ;

Palti, Y .

CANCER RESEARCH, 2004, 64 (09) :3288-3295

← 1 2 3 →