An esophageal gastrointestinal stromal tumor with regional lymph node metastasis

被引：6
作者：
Matsumoto, Sohei [1 ]
Takayama, Tomoyoshi [1 ]
Wakatsuki, Kohei [1 ]
Enomoto, Koji [1 ]
Tanaka, Tetsuya [1 ]
Migita, Kazuhiro [1 ]
Takano, Masato [2 ]
Nakajima, Yoshiyuki [1 ]
机构：
[1] Nara Med Univ, Sch Med, Dept Surg, Nara 6348522, Japan
[2] Nara Med Univ, Sch Med, Dept Diagnost Pathol, Nara 6348522, Japan
来源：
ESOPHAGUS | 2010年 / 7卷 / 02期
关键词：
Gastrointestinal stromal tumor; Esophagus; Lymph node metastasis; IMATINIB MESYLATE; TYROSINE KINASE; DIAGNOSIS; TRIAL; GIST; KIT; ENUCLEATION; RESECTION;
D O I：
10.1007/s10388-010-0231-y
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
We report a case of a 72-year-old woman with an esophageal gastrointestinal stromal tumor (GIST) with regional lymph node metastasis. Endoscopy and barium esophagography revealed a large submucosal tumor in the lower esophagus. Computed tomography showed a solid 8-cm tumor, suggesting an esophageal mesenchymal tumor. Endoscopic ultrasonography-guided fine-needle aspiration biopsy was positive for c-KIT and CD34, and negative for desmin and S-100. The patient underwent middle and lower esophagectomy via left thoracotomy, followed by gastric tube reconstruction. The tumor was completely resected, but a metastasis in the right paracardial lymph node was observed. Pathological examination confirmed the tumor to be high risk. We are carefully following up the patient.
引用
收藏
页码：115 / 118
页数：4
相关论文
共 18 条
  • [1] Lymph node metastasis in gastrointestinal stromal tumours (GIST) occurs preferentially in young patients ≤40 years: an overview based on our case material and the literature
    Agaimy, Abbas
    Wunsch, Peter H.
    [J]. LANGENBECKS ARCHIVES OF SURGERY, 2009, 394 (02) : 375 - 381
  • [2] Endoscopic sonographically guided fine-needle aspiration yield in submucosal tumors of the gastrointestinal tract
    Arantes, V
    Logroño, R
    Faruqi, S
    Ahmed, I
    Waxman, I
    Bhutani, MS
    [J]. JOURNAL OF ULTRASOUND IN MEDICINE, 2004, 23 (09) : 1141 - 1150
  • [3] Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT
    Blanke, Charles D.
    Demetri, George D.
    von Mehren, Margaret
    Heinrich, Michael C.
    Eisenberg, Burton
    Fletcher, Jonathan A.
    Corless, Christopher L.
    Fletcher, Christopher D. M.
    Roberts, Peter J.
    Heinz, Daniela
    Wehre, Elisabeth
    Nikolova, Zariana
    Joensuu, Heikki
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (04) : 620 - 625
  • [4] Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033
    Blanke, Charles D.
    Rankin, Cathryn
    Demetri, George D.
    Ryan, Christopher W.
    von Mehren, Margaret
    Benjamin, Robert S.
    Raymond, A. Kevin
    Bramwell, Vivien H. C.
    Baker, Laurence H.
    Maki, Robert G.
    Tanaka, Michael
    Hecht, J. Randolph
    Heinrich, Michael C.
    Fletcher, Christopher D. M.
    Crowley, John J.
    Borden, Ernest C.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (04) : 626 - 632
  • [5] Surgical considerations for the management and resection of esophageal gastrointestinal stromal tumors
    Blum, Matthew G.
    Bilimoria, Karl Y.
    Wayne, Jeffrey D.
    de Hoyos, Alberto L.
    Talamonti, Mark S.
    Adley, Brian
    [J]. ANNALS OF THORACIC SURGERY, 2007, 84 (05) : 1717 - 1723
  • [6] Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial
    DeMatteo, Ronald P.
    Ballman, Karla V.
    Antonescu, Cristina R.
    Maki, Robert G.
    Pisters, Peter W. T.
    Demetri, George D.
    Blackstein, Martin E.
    Blanke, Charles D.
    von Mehren, Margaret
    Brennan, Murray F.
    Patel, Shreyaskumar
    McCarter, Martin D.
    Polikoff, Jonathan A.
    Tan, Benjamin R.
    Owzar, Kouros
    [J]. LANCET, 2009, 373 (9669) : 1097 - 1104
  • [7] Thoracoscopic enucleation of a giant submucosal tumor of the esophagus
    Ertem, M
    Baca, B
    Dogusoy, G
    Ergüney, S
    Yavuz, N
    [J]. SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES, 2004, 14 (02) : 87 - 90
  • [8] Diagnosis of gastrointestinal stromal tumors: A consensus approach
    Fletcher, CDM
    Berman, JJ
    Corless, C
    Gorstein, F
    Lasota, J
    Longley, BJ
    Miettinen, M
    O'Leary, TJ
    Remotti, H
    Rubin, BP
    Shmookler, B
    Sobin, LH
    Weiss, SW
    [J]. HUMAN PATHOLOGY, 2002, 33 (05) : 459 - 465
  • [9] Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
    Hirota, S
    Isozaki, K
    Moriyama, Y
    Hashimoto, K
    Nishida, T
    Ishiguro, S
    Kawano, K
    Hanada, M
    Kurata, A
    Takeda, M
    Tunio, GM
    Matsuzawa, Y
    Kanakura, Y
    Shinomura, Y
    Kitamura, Y
    [J]. SCIENCE, 1998, 279 (5350) : 577 - 580
  • [10] Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor.
    Joensuu, H
    Roberts, PJ
    Sarlomo-Rikala, M
    Andersson, LC
    Tervahartiala, P
    Tuveson, D
    Silberman, SL
    Capdeville, R
    Dimitrijevic, S
    Druker, B
    Demetri, GD
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (14) : 1052 - 1056
12