In order to effectively suppress the negative effects of salt ions contained in saline soils on agricultural soil quality and crop growth, this study took advantage of the water-saving properties and better soil improvement properties of poly-gamma-glutamic acid (gamma-PGA). By carrying out various experiments, the following relationships have been found. (1) The lab experiment studies the effect of the gamma-PGA application on the infiltration of sandy loam soil. The application rates of gamma-PGA are 0%, 0.1%, 0.2%, and 0.3%, respectively. (2) HYDRUS-1D is used to simulate water infiltration of sandy loam soil under multiple factors (bulk density, gamma-PGA application rate, and the application depth of gamma-PGA). (3) The effect of gamma-PGA on soil solute (Cl-) transport is also explored in this paper. The results show that bulk density and the application depth of gamma-PGA (p < 0.01) have higher effects on cumulative infiltration than the application amount of gamma-PGA (p < 0.05). A lower gamma-PGA application rate will increase the proportion of unavailable soil water by 3%. The established empirical models have good results. Furthermore, when the gamma-PGA application rate is 0.3% (0.02-cm(2) min(-1)), the Cl- hydrodynamic dispersion coefficient is the highest. The study recommends applying the gamma-PGA at 1.4 g cm(-3), 5-20 cm, and 0.2%. The results of this study are conducive to an in-depth understanding of the physicochemical properties of poly-gamma-glutamic acid, improving the utilization rate of salinized land, achieving agricultural water and fertilizer conservation and yield enhancement, and guaranteeing sustainable land use and sustainable development of agroecological environment.