Lehualides E-K, Cytotoxic Metabolites from the Tongan Marine Sponge Plakortis sp.

被引：9
|
作者：
Barber, Jacqueline M. [1 ]
Quek, Natelle C. H. [2 ]
Leahy, Dora C. [2 ]
Miller, John H. [2 ]
Bellows, David S. [2 ]
Northcote, Peter T. [1 ]
机构：
[1] Victoria Univ Wellington, Sch Chem & Phys Sci, Wellington, New Zealand
[2] Victoria Univ Wellington, Sch Biol Sci, Wellington, New Zealand
来源：
JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 04期
关键词：
SACCHAROMYCES-CEREVISIAE; ABC TRANSPORTERS; BETA-CARBOLINES; ALPHA-PYRONE; A-D; DERIVATIVES; SULFOXIDE; PEROXIDES; OXIDATION; SULFIDES;
D O I：
10.1021/np100868t
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Spectroscopy-guided chemical analysis of a marine sponge from the genus Plakortis, collected in Tonga, yielded., seven, new metabolites, of polyketide origin, lehualides E-K (5 11), four of which incorporate various sulfur functionalities. The strUctures of compounds 5-11 were elucidated by interpretation of spectroscopic data and spectral comparison with model compounds. The biological activities of compounds 6-9 were investigated against human promyeloid leukemic HL-60 cells and two yeast strains, wild type and a drug sensitive mutant.
引用
收藏
页码：809 / 815
页数：7
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