New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis

被引：15

作者：

Yoshida, Osamu ^{[1
]}

Nakamura, Jun ^{[2
]}

Yamashiro, Hidenori ^{[1
]}

Miura, Kenji ^{[1
]}

Hayashi, Sayaka ^{[2
]}

Umetsu, Kosei ^{[2
]}

Xu, Shu ^{[2
]}

Maki, Hideki ^{[1
]}

Arimoto, Hirokazu ^{[2
]}

机构：

[1] Shionogi & Co Ltd, Discovery Res Labs, Osaka 5610825, Japan

[2] Tohoku Univ, Grad Sch Life Sci, Sendai, Miyagi 9808577, Japan

来源：

MEDCHEMCOMM | 2011年 / 2卷 / 04期

关键词：

RESISTANT STAPHYLOCOCCUS-AUREUS; GLYCOPEPTIDE; BINDING; LIPOGLYCOPEPTIDE; ANTIBIOTICS; TELAVANCIN;

D O I：

10.1039/c0md00230e

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The emergence of vancomycin-resistant bacteria has created an urgent need for new active analogues of vancomycin. We previously reported vancomycin dimers with in vivo antibacterial activity. Here, we provide the first experimental insights into their inhibitory actions in bacterial cell wall synthesis.

引用

页码：278 / 282

页数：5

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