Does ammonia production by Klebsiella contribute to pathogenesis?

被引：13
作者：
Kleiner, D [1 ]
Traglauer, A [1 ]
Domm, S [1 ]
机构：
[1] Univ Bayreuth, Dept Microbiol, D-95440 Bayreuth, Germany
来源：
BULLETIN DE L INSTITUT PASTEUR | 1998年 / 96卷 / 04期
关键词：
ammonification; protease; Klebsiella; ammonia; ureolysis; virulence factors; toxicity; permeability; review;
D O I：
10.1016/S0020-2452(99)80006-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
High ammonia levels in mammalian tissues, especially blood (as well as in urine), are toxic, causing severe metabolic disorders. The underlying pathogenic principles are for the most part poorly understood. In this review we discuss 1) possible mechanisms of ammonia toxicity, 2) general mechanisms of bacterial ammonia production and 3) Klebsiella virulence. Special reference is made to possible effects of nitrogen fixation, ureolysis, proteolysis and amino acid ammonification.
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收藏
页码：257 / 265
页数：9
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