Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications

被引：563

作者：

Schante, Carole E. ^{[1
,2
]}

Zuber, Guy ^{[1
]}

Herlin, Corinne ^{[2
]}

Vandamme, Thierry F. ^{[1
]}

机构：

[1] Univ Strasbourg, Lab Concept & Applicat Mol Bioact, UMR7199, Fac Pharm, F-67400 Illkirch Graffenstaden, France

[2] Lab IDENOV, F-67000 Strasbourg, France

来源：

CARBOHYDRATE POLYMERS | 2011年 / 85卷 / 03期

关键词：

Hyaluronic acid derivative; Chemical modification; Crosslinking; Conjugation; Drug delivery; Characterization; DRUG-DELIVERY SYSTEMS; IN-VITRO EVALUATION; CROSS-LINKING; RHEOLOGICAL CHARACTERIZATION; FUNCTIONALIZED DERIVATIVES; POLYSACCHARIDE HYDROGELS; TISSUE AUGMENTATION; PHYSICAL-PROPERTIES; SODIUM HYALURONATE; ANTITUMOR-ACTIVITY;

D O I：

10.1016/j.carbpol.2011.03.019

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Hyaluronic acid (HA) is widely used for numerous medical applications, such as viscosupplementation, eye surgery and drug delivery. A broad range of HA-based materials have been developed and described for the enhancement, modulation and control of its therapeutic action, based on chemical modification of polysaccharides. The purpose of this paper is to review the various chemical modification methods and synthetic routes to obtain HA derivatives, encompassing all applications. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：469 / 489

页数：21

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