Polydatin Ameliorates DSS-Induced Colitis in Mice through Inhibition of Nuclear Factor-kappaB Activation

被引：45

作者：

Yao, Jun ^{[1
]}

Wang, Jian-Yao ^{[2
]}

Liu, Lei ^{[2
]}

Zeng, Wei-Sen ^{[3
]}

Li, Ying-Xue ^{[1
]}

Xun, An-Ying ^{[4
]}

Zhao, Li ^{[3
]}

Jia, Chun-Hong ^{[3
]}

Feng, Ju-Ling ^{[1
]}

Wei, Xiao-Xia ^{[1
]}

Wang, Li-Sheng ^{[1
]}

机构：

[1] Jinan Univ Med Sci, Dept Gastroenterol, Shenzhen Municipal Peoples Hosp, Shenzhen 518020, Guangdong, Peoples R China

[2] Shenzhen Childrens Hosp, Dept Gen Surg, Shenzhen, Guangdong, Peoples R China

[3] So Med Univ, Dept Cell Biol, Guangzhou, Guangdong, Peoples R China

[4] Peking Univ, Shenzhen Hosp, Dept Gastroenterol, Shenzhen, Guangdong, Peoples R China

来源：

PLANTA MEDICA | 2011年 / 77卷 / 05期

关键词：

nuclear factor-kappa B; polydatin; resveratrol; ulcerative colitis; SODIUM-INDUCED COLITIS; ULCERATIVE-COLITIS; COLONIC INFLAMMATION; B ACTIVATION; ANTIOXIDANT; PICEID; RATS; RESVERATROL; GLUCOSIDASE; DISEASE;

D O I：

10.1055/s-0030-1250462

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nuclear factor-kappa B (NF-kappa B) plays a pivotal role in the regulation of immune and inflammatory responses. The real-time expression level of NF-kappa B reflects the development of ulcerative colitis (UC). Polydatin has vast pharmacological activities, including inhibiting the production of inflammatory mediators, inducing the production of antioxidants, regulating immune function, etc. The purpose of this study was to investigate the potential inhibitory effects of polydatin on NF-kappa B pathway activation in a mouse UC model. The results showed that polydatin treatment downregulated NF-kappa B p65 activity and expression, blocked the expression of TNF-alpha, IL-6 and IL-1 beta at both mRNA and protein levels, decreased myeloperoxidase (MPO) activity, and alleviated inflammatory damage of colitis in mice with UC (p < 0.05), suggesting that the anti-inflammation effects of polydatin can be attributed, at least partially, to the blocking of the NF-kappa B pathway.

引用

页码：421 / 427

页数：7

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