Pathophysiology of RAGE in inflammatory diseases

被引：90

作者：

Dong, Hanbing ^{[1
]}

Zhang, Yue ^{[1
]}

Huang, Yu ^{[1
]}

Deng, Hui ^{[1
]}

机构：

[1] Jilin Univ, Hosp 1, Dept Neurol & Neurosci Ctr, Changchun, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

RAGE; ligands; signaling; inflammatory diseases; RAGE inhibitors; GLYCATION END-PRODUCTS; GROUP BOX 1; CELL-SURFACE-RECEPTOR; A-BETA ACCUMULATION; BLOOD-BRAIN-BARRIER; LYSOPHOSPHATIDIC ACID; S100; PROTEINS; PARKINSONS-DISEASE; MULTIPLE-SCLEROSIS; OXIDATIVE STRESS;

D O I：

10.3389/fimmu.2022.931473

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The receptor for advanced glycation end products (RAGE) is a non-specific multi-ligand pattern recognition receptor capable of binding to a range of structurally diverse ligands, expressed on a variety of cell types, and performing different functions. The ligand-RAGE axis can trigger a range of signaling events that are associated with diabetes and its complications, neurological disorders, cancer, inflammation and other diseases. Since RAGE is involved in the pathophysiological processes of many diseases, targeting RAGE may be an effective strategy to block RAGE signaling.

引用

页数：16

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