Physics and Physiology of Cell Spreading in Two and Three Dimensions

被引：17
作者：
Janmey, Paul A. [1 ]
Hinz, Boris [2 ]
McCllioch, Christopher A. [2 ]
机构：
[1] Univ Penn, Inst Med & Engn, Dept Physiol, Philadelphia, PA 19104 USA
[2] Univ Toronto, Fac Dent, Toronto, ON, Canada
来源：
PHYSIOLOGY | 2021年 / 36卷 / 06期
基金：
加拿大创新基金会; 美国国家卫生研究院; 加拿大健康研究院; 美国国家科学基金会;
关键词：
focal adhesion; actin; fibrosis; thermal ratchet; ENUCLEATED CELLS; ADHESION; MIGRATION; MEMBRANE; MOTILITY; DRIVES; AUGMENTATION; POLARIZATION; IMPLANTS; INVASION;
D O I：
10.1152/physiol.00020.2021
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Cells spread on surfaces and within three-dimensional (3-D) matrixes as they grow, divide, and move. Both chemical and physical signals orchestrate spreading during normal development, wound healing, and pathological states such as fibrosis and tumor growth. Diverse molecular mechanisms drive different forms of cell spreading. This article discusses mechanisms by which cells spread in 2-D and 3-D and illustrates new directions in studies of this aspect of cell function.
引用
收藏
页码：382 / 391
页数：10
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