In vitro study of chlorin YLG-1 mediated photodynamic effect on human cancer cells

被引：0

作者：

Meng, Na ^{[1
]}

Wang, Xin ^{[1
]}

Jiang, Jie ^{[1
]}

Ding, Rui ^{[2
]}

Han, Zhen ^{[2
]}

Huang, Zheng ^{[1
]}

机构：

[1] Fujian Normal Univ, Sch Optoelect & Informat Engn, Key Lab Photon Technol Fujian Prov, MOE Key Lab Med Optoelect Sci & Technol, Fuzhou 350007, Peoples R China

[2] Guilin Hui Ang Biopharmoceut Co Ltd, Guilin 541004, Peoples R China

来源：

OPTICS IN HEALTH CARE AND BIOMEDICAL OPTICS XI | 2021年 / 11900卷

基金：

中国国家自然科学基金;

关键词：

photodynamic therapy; human cancer cells; YLG-1; chlorin; PORPHYRIN; THERAPY;

D O I：

10.1117/12.2600758

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Photosensitizer is a key element of photodynamic therapy (PDT). Currently, only limited numbers of photosensitizers are available for antitumor PDT in China. YLG-1 (Ang-Da-Fen-Qi) is a newly developed second-generation chlorin-type photosensitizer. In this preliminary study, the killing effect of combination of YLG- 1 and 652 nm diode laser on human nasopharyngeal carcinoma cells and human ovarian cancer cells were investigated. In vitro study suggests that YLG-1 mediated PDT activity has strong cancer cell killing effect and therefore potentials for antitumor PDT applications.

引用

页数：7

共 11 条

[1]

Ding Z. J., Chinese Patent, Patent No. [CN104086554B (2106), 1040865542106]

[2] Photodynamic therapy for cancer [J].