Paternal irradiation perturbs the expression of circadian genes in offspring

被引：10

作者：

Gomes, Andre M. G. F. ^{[1
]}

Barber, Ruth C. ^{[1
]}

Dubrova, Yuri E. ^{[1
]}

机构：

[1] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2015年 / 775卷

关键词：

Radiation; Gene expression; Microarrays; Circadian system; Transgenerational instability; TRANSGENERATIONAL GENOMIC INSTABILITY; DNA-DAMAGE; MALE-MICE; MUTATION; INDUCTION; STABILITY; RADIATION; EXPOSURE; CLOCK;

D O I：

10.1016/j.mrfmmm.2015.03.007

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The circadian system represents a complex network which influences the timing of many biological processes. Recent studies have established that circadian alterations play an important role in the susceptibility to many human diseases, including cancer. Here we report that paternal irradiation in mice significantly affects the expression of genes involved in rhythmic processes in their first-generation offspring. Using microarrays, the patterns of gene expression were established for brain, kidney, liver and spleen samples from the non-exposed offspring of irradiated CBA/Ca and BALB/c male mice. The most over-represented categories among the genes differentially expressed in the offspring of control and irradiated males were those involved in rhythmic process, circadian rhythm and DNA-dependent regulation of transcription. The results of our study therefore provide a plausible explanation for the transgenerational effects of paternal irradiation, including increased transgenerational carcinogenesis described in other studies. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：33 / 37

页数：5

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