Tirucallane Triterpenoids from Cornus walteri

被引：42
作者：
Kim, Ki Hyun [1 ]
Choi, Sang Un [2 ]
Kim, Young Choong [3 ]
Lee, Kang Ro [1 ]
机构：
[1] Sungkyunkwan Univ, Sch Pharm, Nat Prod Lab, Suwon 440746, South Korea
[2] Korea Res Inst Chem Technol, Teajeon 305600, South Korea
[3] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
来源：
JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 01期
关键词：
FRUITS; DERIVATIVES; LIGNANS;
D O I：
10.1021/np100660v
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Twelve new tirucallane triterpenoids, named cornusalterins A-L (1-12), and two known tirucallane triterpenoids, deoxyflindissone (13) and (-)-leucophyllone (14), were isolated from a MeOH extract of stems and stem bark of Cornus walteri. The structures of the new compounds were determined by spectroscopic methods, including ID and 2D NMR analyses. Compounds 12 and 13, possessing a tetrahydrofuran ring in the side chain, exhibited significant cytotoxic activity against the A549, SK-OV-3, SK-MEL-2, and XF498 cell lines.
引用
收藏
页码：54 / 59
页数：6
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