NIR-II bioimaging of small molecule fluorophores: From basic research to clinical applications

被引：45

作者：

Li, Chonglu ^{[1
,2
]}

Guan, Xiaofang ^{[2
]}

Zhang, Xian ^{[2
]}

Zhou, Di ^{[3
]}

Son, Subin ^{[4
]}

Xu, Yunjie ^{[4
]}

Deng, Mengtian ^{[1
]}

Guo, Zhenzhong ^{[1
]}

Sun, Yao ^{[2
]}

Kim, Jong Seung ^{[4
]}

机构：

[1] Wuhan Univ Sci & Technol, Hubei Prov Key Lab Occupat Hazard Identificat & Co, Wuhan 430065, Peoples R China

[2] Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Expt Med Ctr, Wuhan 430074, Peoples R China

[4] Korea Univ, Dept Chem, Seoul 02841, South Korea

来源：

BIOSENSORS & BIOELECTRONICS | 2022年 / 216卷

基金：

中国国家自然科学基金; 新加坡国家研究基金会;

关键词：

NIR-II bioimaging Small-molecule fluorophores; Preclinical practice; Disease diagnosis; RATIONAL DESIGN; FLUORESCENCE; DYES; DELIVERY; TUMORS; LIVER; EXPRESSION; EMISSION; STRATEGY; DONOR;

D O I：

10.1016/j.bios.2022.114620

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Due to the low autofluorescence and deep-photo penetration, the second near-infrared region fluorescence im-aging technology (NIR-II, 1000-2000 nm) has been widely utilized in basic scientific research and preclinical practice throughout the past decade. The most attractive candidates for clinical translation are organic NIR-II fluorophores with a small-molecule framework, owing to their low toxicity, high synthetic repeatability, and simplicity of chemical modification. In order to enhance the translation of small molecule applications in NIR-II bioimaging, NIR-II fluorescence imaging technology has evolved from its usage in cells to the diagnosis of dis-eases in large animals and even humans. Although several examples of NIR-II fluorescence imaging have been used in preclinical studies, there are still many challenges that need to be addressed before they can finally be used in clinical settings. In this paper, we reviewed the evolution of the chemical structures and photophysical properties of small-molecule fluorophores, with an emphasis on their biomedical applications ranging from small animals to humans. We also explored the potential of small-molecule fluorophores.

引用

页数：12

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