A novel and effective chiral phosphoramide catalyst for the borane-mediated asymmetric reduction of prochiral α-halo ketones

被引：28
|
作者：
Basavaiah, D [1 ]
Reddy, GJ [1 ]
Chandrashekar, V [1 ]
机构：
[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India
来源：
TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 04期
关键词：
D O I：
10.1016/S0957-4166(01)00101-X
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The novel chiral phosphoramide, 1,4-bis[(5S)-1,3-diaza-2-phospha-2-oxo-3-phenylbicyclo(3.3.0)octan-2-yl]piperazine, was synthesised and successfully employed as a catalyst in the borane-mediated asymmetric reductions of prochiral cc-halo ketones, providing the corresponding a-halo alcohols in 90-95% enantiomeric purities. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：685 / 689
页数：5
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