CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications

被引：1

作者：

Bang, Seongsik ^{[1
]}

Jee, Seungyun ^{[1
]}

Son, Hwangkyu ^{[1
]}

Cha, Hyebin ^{[1
]}

Park, Hosub ^{[1
]}

Myung, Jaekyung ^{[1
]}

Ko, Joo Yeon ^{[2
]}

Kim, Hyunsung ^{[1
]}

Paik, Seungsam ^{[1
]}

机构：

[1] Hanyang Univ, Seoul Hosp, Dept Pathol, Coll Med, Seoul 04763, South Korea

[2] Hanyang Univ, Seoul Hosp, Dept Dermatol, Coll Med, Seoul 04763, South Korea

来源：

DIAGNOSTICS | 2022年 / 12卷 / 08期

关键词：

non-melanoma skin cancer; basal cell carcinoma; squamous cell carcinoma; CD47; immunohistochemistry; BASAL-CELL CARCINOMA; TARGET;

D O I：

10.3390/diagnostics12081859

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CD47 is a cell surface molecule and regulates diverse cellular responses. CD47 is highly expressed in cancer cells and has potential as a therapeutic target and prognostic factor in cancer patients. The expression patterns of CD47 in basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and its precursor lesions, and its clinicopathological significance were investigated. CD47 expression was evaluated by immunohistochemistry in 152 cases of BCC and 71 cases of SCC. For comparison of CD47 expression, actinic keratosis (AK), squamous cell carcinoma in situ (SCCIS), keratoacanthoma (KA), and normal skin (NS) tissue were used. CD47 expression in BCC was significantly lower than that of SCC (p < 0.001). CD47 expression levels in SCC and KA were significantly higher than those of NS and AK (p < 0.05). High CD47 expression was significantly associated with the presence of ulceration (p = 0.005) and a deeper level of invasion (p = 0.011) in BCC. In addition, high CD47 expression was significantly associated with the presence of ulceration (p = 0.019) and larger tumor size (p = 0.004) in SCC. CD47 expression was associated with tumorigenesis and tumor progression in non-melanoma skin cancers.

引用

页数：9

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