CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?

被引：883
作者：
Zoeller, Margot [1 ,2 ]
机构：
[1] Univ Hosp Surg, Dept Tumour Cell Biol, D-69120 Heidelberg, Germany
[2] German Canc Res Ctr, D-69120 Heidelberg, Germany
来源：
NATURE REVIEWS CANCER | 2011年 / 11卷 / 04期
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; LYMPHOCYTE HOMING RECEPTOR; METASTATIC BREAST-CANCER; NORMAL STEM-CELLS; COMPLEX-FORMATION; CARCINOMA CELLS; DRUG-RESISTANCE; HEPARAN-SULFATE; TGF-BETA; BIVATUZUMAB MERTANSINE;
D O I：
10.1038/nrc3023
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Can an abundantly expressed molecule be a reliable marker for the cancer-initiating cells (CICs; also known as cancer stem cells), which constitute the minority of cells within the mass of a tumour? CD44 has been implicated as a CIC marker in several malignancies of haematopoietic and epithelial origin. Is this a fortuitous coincidence owing to the widespread expression of the molecule or is CD44 expression advantageous as it fulfils some of the special properties that are displayed by CICs, such as self-renewal, niche preparation, epithelial-mesenchymal transition and resistance to apoptosis?
引用
收藏
页码：254 / 267
页数：14
相关论文
共 193 条
  • [1] Fibroblast migration is mediated by CD44-dependent TGFβ activation
    Acharya, Pinak S.
    Majumdar, Sonali
    Jacob, Michele
    Hayden, James
    Mrass, Paul
    Weninger, Wolfgang
    Assoian, Richard K.
    Pure, Ellen
    [J]. JOURNAL OF CELL SCIENCE, 2008, 121 (09) : 1393 - 1402
  • [2] Adamia Sophia, 2005, Current Drug Targets - Cardiovascular & Haematological Disorders, V5, P3, DOI 10.2174/1568006053005056
  • [3] Is tumor growth sustained by rare cancer stem cells or dominant clones?
    Adams, Jerry M.
    Strasser, Andreas
    [J]. CANCER RESEARCH, 2008, 68 (11) : 4018 - 4021
  • [4] Epithelial Mesenchymal Transition and Cancer Stem Cell-Like Phenotypes Facilitate Chemoresistance in Recurrent Ovarian Cancer
    Ahmed, N.
    Abubaker, K.
    Findlay, J.
    Quinn, M.
    [J]. CURRENT CANCER DRUG TARGETS, 2010, 10 (03) : 268 - 278
  • [5] Akisik Elif, 2002, Pathology and Oncology Research, V8, P36
  • [6] Allan Alison L, 2006, Breast Dis, V26, P87
  • [7] Ligation of the CD44 adhesion molecule inhibits drug-induced apoptosis in human myeloid leukemia cells
    Allouche, M
    Charrad, RS
    Bettaieb, A
    Greenland, C
    Grignon, C
    Smadja-Joffe, F
    [J]. BLOOD, 2000, 96 (03) : 1187 - 1190
  • [8] Hyaluronan
    Almond, A.
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2007, 64 (13) : 1591 - 1596
  • [9] TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma
    Anido, Judit
    Saez-Borderias, Andrea
    Gonzalez-Junca, Alba
    Rodon, Laura
    Folch, Gerard
    Carmona, Maria A.
    Prieto-Sanchez, Rosa M.
    Barba, Ignasi
    Martinez-Saez, Elena
    Prudkin, Ludmila
    Cuartas, Isabel
    Raventos, Carolina
    Martinez-Ricarte, Francisco
    Antonia Poca, M.
    Garcia-Dorado, David
    Lahn, Michael M.
    Yingling, Jonathan M.
    Rodon, Jordi
    Sahuquillo, Juan
    Baselga, Jose
    Seoane, Joan
    [J]. CANCER CELL, 2010, 18 (06) : 655 - 668
  • [10] Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
    Arai, F
    Hirao, A
    Ohmura, M
    Sato, H
    Matsuoka, S
    Takubo, K
    Ito, K
    Koh, GY
    Suda, T
    [J]. CELL, 2004, 118 (02) : 149 - 161
12345678910