CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?

被引：896
作者：
Zoeller, Margot [1 ,2 ]
机构：
[1] Univ Hosp Surg, Dept Tumour Cell Biol, D-69120 Heidelberg, Germany
[2] German Canc Res Ctr, D-69120 Heidelberg, Germany
来源：
NATURE REVIEWS CANCER | 2011年 / 11卷 / 04期
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; LYMPHOCYTE HOMING RECEPTOR; METASTATIC BREAST-CANCER; NORMAL STEM-CELLS; COMPLEX-FORMATION; CARCINOMA CELLS; DRUG-RESISTANCE; HEPARAN-SULFATE; TGF-BETA; BIVATUZUMAB MERTANSINE;
D O I：
10.1038/nrc3023
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Can an abundantly expressed molecule be a reliable marker for the cancer-initiating cells (CICs; also known as cancer stem cells), which constitute the minority of cells within the mass of a tumour? CD44 has been implicated as a CIC marker in several malignancies of haematopoietic and epithelial origin. Is this a fortuitous coincidence owing to the widespread expression of the molecule or is CD44 expression advantageous as it fulfils some of the special properties that are displayed by CICs, such as self-renewal, niche preparation, epithelial-mesenchymal transition and resistance to apoptosis?
引用
收藏
页码：254 / 267
页数：14
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