A Guide to ComBat Harmonization of Imaging Biomarkers in Multicenter Studies

被引：136

作者：

Orlhac, Fanny ^{[1
]}

Eertink, Jakoba J. ^{[2
]}

Cottereau, Anne-Segolene ^{[1
,3
]}

Zijlstra, Josee M. ^{[2
]}

Thieblemont, Catherine ^{[4
,5
]}

Meignan, Michel ^{[6
]}

Boellaard, Ronald ^{[7
]}

Buvat, Irene ^{[1
]}

机构：

[1] Univ Paris Saclay, Univ PSL, Inst Curie, INSERM,LITOU1288, Orsay, France

[2] Vrije Univ Amsterdam, Amsterdam UMC, Dept Hematol, Canc Ctr Amsterdam, Amsterdam, Netherlands

[3] Univ ParisDescartes, Hop Cochin, AP HP, Dept Nucl Med, Paris, France

[4] Univ Paris, Hopl St Louis, AP HP, DMU DHI,Dept Hematooncol, Paris, France

[5] Univ Paris, NF KappaB Differenciat & Canc, Paris, France

[6] Univ Paris Est, Hop Henri Mondor, AP HP, Lysa Imaging, Creteil, France

[7] Vrije Univ Amsterdam, Amsterdam UMC, Dept Radiol & Nucl Med, Canc Ctr Amsterdam, Amsterdam, Netherlands

来源：

JOURNAL OF NUCLEAR MEDICINE | 2022年 / 63卷 / 02期

关键词：

radiomics; harmonization; texture analysis; multicenter studies; RECONSTRUCTION SETTINGS; LYMPHOMA; FEATURES; IMPACT;

D O I：

10.2967/jnumed.121.262464

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The impact of PET image acquisition and reconstruction parameters on SUV measurements or radiomic feature values is widely documented. This scanner effect is detrimental to the design and validation of predictive or prognostic models and limits the use of large multicenter cohorts. To reduce the impact of this scanner effect, the ComBat method has been proposed and is now used in various contexts. The purpose of this article is to explain and illustrate the use of ComBat based on practical examples. We also give examples in which the ComBat assumptions are not met and, thus, in which ComBat should not be used.

引用

页码：172 / 179

页数：8

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