Exercising immune cells: The immunomodulatory role of exercise on atrial fibrillation

被引：6
作者：
Miguel-dos-Santos, Rodrigo [1 ,2 ]
Moreira, Jose Bianco Nascimento [2 ]
Loennechen, Jan Pal [2 ,3 ]
Wisloff, Ulrik [2 ,4 ]
Mesquita, Thassio [5 ]
机构：
[1] Univ Fed Sergipe, Dept Physiol, Sergipe, Brazil
[2] Norwegian Univ Sci & Technol NTNU, Dept Circulat & Med Imaging, Cardiac Exercise Res Grp CERG, Trondheim, Norway
[3] St Olavs Univ Hosp, Dept Cardiol, Trondheim, Norway
[4] Univ Queensland, Sch Human Movement & Nutr Sci, Queensland, Australia
[5] Cedars Sinai Med Ctr, Smidt Heart Inst, 127 S San Vicente Blvd, Los Angeles, CA 90048 USA
来源：
PROGRESS IN CARDIOVASCULAR DISEASES | 2021年 / 68卷
关键词：
Exercise training; Atrial fibrillation; Inflammation; Innate immune system; Atrial remodeling; Fibrosis; IMPROVES CARDIAC-FUNCTION; REGULAR PHYSICAL-ACTIVITY; RESTING HEART-RATE; MYOCARDIAL-INFARCTION; NLRP3; INFLAMMASOME; CALCIUM LEAK; RISK-FACTORS; CARDIORESPIRATORY FITNESS; FKBP12.6; DEFICIENCY; POSSIBLE MECHANISMS;
D O I：
10.1016/j.pcad.2021.07.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Exercise training is generally beneficial for cardiovascular health, improving stroke volume, cardiac output, and aerobic capacity. Despite these benefits, some evidence indicates that endurance training may increase the risk of atrial fibrillation (AF), particularly in highly trained individuals. Among multiple mechanisms, autonomic tone changes and atrial remodeling have been proposed as main contributors for exercise-induced AF. However, the contribution of local and systemic immunity is poorly understood in the development of atrial arrhythmogenic substrates. Here we aim to update the field of immunomodulation in the context of exercise and AF by compiling and reconciling the most recent evidence from preclinical and human studies and rationalize the applicability of "lone" AF terminology in athletes. (c) 2021 Published by Elsevier Inc.
引用
收藏
页码：52 / 59
页数：8
相关论文
共 143 条
  • [61] Exercise training improves cardiac function and attenuates arrhythmia in CPVT mice
    Kurtzwald-Josefson, Efrat
    Hochhauser, Edith
    Katz, Guy
    Porat, Eyal
    Seidman, Jonathan G.
    Seidman, Christine E.
    Chepurko, Yelena
    Shainberg, Asher
    Eldar, Michael
    Arad, Michael
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 2012, 113 (11) : 1677 - 1683
  • [62] Lower than expected desmosomal gene mutation prevalence in endurance athletes with complex ventricular arrhythmias of right ventricular origin
    La Gerche, A.
    Robberecht, C.
    Kuiperi, C.
    Nuyens, D.
    Willems, R.
    de Ravel, T.
    Matthijs, G.
    Heidbuchel, H.
    [J]. HEART, 2010, 96 (16) : 1268 - 1274
  • [63] Inhibition of soluble TNFα prevents adverse atrial remodeling and atrial arrhythmia susceptibility induced in mice by endurance exercise
    Lakin, Robert
    Polidovitch, Nazari
    Yang, Sibao
    Guzman, Camilo
    Gao, Xiaodong
    Wauchop, Marianne
    Burns, Jacob
    Izaddoustdar, Farzad
    Backx, Peter H.
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2019, 129 : 165 - 173
  • [64] Systemic Inflammation Rapidly Induces Reversible Atrial Electrical Remodeling: The Role of Interleukin-6 Mediated Changes in Connexin Expression
    Lazzerini, Pietro Enea
    Laghi-Pasini, Franco
    Acampa, Maurizio
    Srivastava, Ujala
    Bertolozzi, Iacopo
    Giabbani, Beatrice
    Finizola, Francesco
    Vanni, Francesca
    Dokollari, Aleksander
    Natale, Mariarita
    Cevenini, Gabriele
    Selvi, Enrico
    Migliacci, Nicola
    Maccherini, Massimo
    Boutjdir, Mohamed
    Capecchi, Pier Leopoldo
    [J]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2019, 8 (16):
  • [65] Physical activity protects NLRP3 inflammasome-associated coronary vascular dysfunction in obese mice
    Lee, Jonghae
    Lee, Yang
    LaVoy, Emily C.
    Umetani, Michihisa
    Hong, Junyoung
    Park, Yoonjung
    [J]. PHYSIOLOGICAL REPORTS, 2018, 6 (12):
  • [66] Tumor necrosis factor-α alters calcium handling and increases arrhythmogenesis of pulmonary vein cardiomyocytes
    Lee, Shih-Huang
    Chen, Yao-Chang
    Chen, Yi-Jen
    Chang, Shih-Lin
    Tai, Ching-Tai
    Wongeharoen, Wanwarang
    Yeh, Hung-I
    Lin, Cheng-I
    Chen, Shih-Ann
    [J]. LIFE SCIENCES, 2007, 80 (19) : 1806 - 1815
  • [67] Catecholaminergic Polymorphic Ventricular Tachycardia
    Leenhardt, Antoine
    Denjoy, Isabelle
    Guicheney, Pascale
    [J]. CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2012, 5 (05) : 1044 - 1052
  • [68] Implication of connexins 40 and 43 in functional coupling between mouse cardiac fibroblasts in primary culture
    Louault, Claire
    Benamer, Najate
    Faivre, Jean-Francois
    Potreau, Daniel
    Bescond, Jocelyn
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2008, 1778 (10): : 2097 - 2104
  • [69] Genetic Risk Prediction of Atrial Fibrillation
    Lubitz, Steven A.
    Yin, Xiaoyan
    Lin, Henry J.
    Kolek, Matthew
    Smith, J. Gustav
    Trompet, Stella
    Rienstra, Michiel
    Rost, Natalia S.
    Teixeira, Pedro L.
    Almgren, Peter
    Anderson, Christopher D.
    Chen, Lin Y.
    Engstrom, Gunnar
    Ford, Ian
    Furie, Karen L.
    Guo, Xiuqing
    Larson, Martin G.
    Lunetta, Kathryn L.
    Macfarlane, Peter W.
    Psaty, Bruce M.
    Soliman, Elsayed Z.
    Sotoodehnia, Nona
    Stott, David J.
    Taylor, Kent D.
    Weng, Lu-Chen
    Yao, Jie
    Geelhoed, Bastiaan
    Verweij, Niek
    Siland, Joylene E.
    Kathiresan, Sekar
    Roselli, Carolina
    Roden, Dan M.
    van der Harst, Pim
    Darbar, Dawood
    Jukema, J. Wouter
    Melander, Olle
    Rosand, Jonathan
    Rotter, Jerome I.
    Heckbert, Susan R.
    Ellinor, Patrick T.
    Alonso, Alvaro
    Benjamin, Emelia J.
    [J]. CIRCULATION, 2017, 135 (14) : 1311 - +
  • [70] Echocardiographic findings in former professional cyclists after long-term deconditioning of more than 30 years
    Luthi, Pia
    Zuber, Michel
    Ritter, Manfred
    Oechslin, Erwin N.
    Jenni, Rolf
    Seifert, Burkhardt
    Baldesberger, Sylvette
    Jost, Christine H. Attenhofer
    [J]. EUROPEAN JOURNAL OF ECHOCARDIOGRAPHY, 2008, 9 (02): : 261 - 267
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