Exercising immune cells: The immunomodulatory role of exercise on atrial fibrillation

被引：6
作者：
Miguel-dos-Santos, Rodrigo [1 ,2 ]
Moreira, Jose Bianco Nascimento [2 ]
Loennechen, Jan Pal [2 ,3 ]
Wisloff, Ulrik [2 ,4 ]
Mesquita, Thassio [5 ]
机构：
[1] Univ Fed Sergipe, Dept Physiol, Sergipe, Brazil
[2] Norwegian Univ Sci & Technol NTNU, Dept Circulat & Med Imaging, Cardiac Exercise Res Grp CERG, Trondheim, Norway
[3] St Olavs Univ Hosp, Dept Cardiol, Trondheim, Norway
[4] Univ Queensland, Sch Human Movement & Nutr Sci, Queensland, Australia
[5] Cedars Sinai Med Ctr, Smidt Heart Inst, 127 S San Vicente Blvd, Los Angeles, CA 90048 USA
来源：
PROGRESS IN CARDIOVASCULAR DISEASES | 2021年 / 68卷
关键词：
Exercise training; Atrial fibrillation; Inflammation; Innate immune system; Atrial remodeling; Fibrosis; IMPROVES CARDIAC-FUNCTION; REGULAR PHYSICAL-ACTIVITY; RESTING HEART-RATE; MYOCARDIAL-INFARCTION; NLRP3; INFLAMMASOME; CALCIUM LEAK; RISK-FACTORS; CARDIORESPIRATORY FITNESS; FKBP12.6; DEFICIENCY; POSSIBLE MECHANISMS;
D O I：
10.1016/j.pcad.2021.07.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Exercise training is generally beneficial for cardiovascular health, improving stroke volume, cardiac output, and aerobic capacity. Despite these benefits, some evidence indicates that endurance training may increase the risk of atrial fibrillation (AF), particularly in highly trained individuals. Among multiple mechanisms, autonomic tone changes and atrial remodeling have been proposed as main contributors for exercise-induced AF. However, the contribution of local and systemic immunity is poorly understood in the development of atrial arrhythmogenic substrates. Here we aim to update the field of immunomodulation in the context of exercise and AF by compiling and reconciling the most recent evidence from preclinical and human studies and rationalize the applicability of "lone" AF terminology in athletes. (c) 2021 Published by Elsevier Inc.
引用
收藏
页码：52 / 59
页数：8
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