RIG-I ligand enhances the immunogenicity of recombinant H7HA protein

被引：6

作者：

Cao, Weiping ^{[1
]}

Liepkalns, Justine S. ^{[1
]}

Kamal, Ram P. ^{[1
,2
]}

Reber, Adrian J. ^{[1
]}

Kim, Jin Hyang ^{[1
]}

Hofstetter, Amelia R. ^{[1
,3
]}

Amoah, Samuel ^{[1
,2
]}

Stevens, James ^{[4
]}

Ranjan, Priya ^{[1
]}

Gangappa, Shivaprakash ^{[1
]}

York, Ian A. ^{[1
]}

Sambhara, Suryaprakash ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Immunol & Pathogenesis Branch, Influenza Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd, Atlanta, GA USA

[2] Battelle Mem Inst, Atlanta, GA USA

[3] Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

[4] Ctr Dis Control & Prevent, Virus Surveillance & Diag Branch, Influenza Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd, Atlanta, GA USA

来源：

CELLULAR IMMUNOLOGY | 2016年 / 304卷

关键词：

H7HA; RIG-I ligand; Cell-mediated immunity; Antibody responses; Protective immunity; Mouse model; Influenza; INFLUENZA-VIRUS; PANDEMIC INFLUENZA; INNATE IMMUNITY; PHASE-I; VACCINE; H5N1; ACTIVATION; INFECTION;

D O I：

10.1016/j.cellimm.2016.04.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Avian H7N9 influenza virus infection with fatal outcomes continues to pose a pandemic threat and highly immunogenic vaccines are urgently needed. In this report we show that baculovirus-derived recombinant H7 hemagglutinin protein, when delivered with RIG-I ligand, induced enhanced antibody and T cell responses and conferred protection against lethal challenge with a homologous H7N9 virus. These findings indicate the potential utility of RIG-I ligands as vaccine adjuvants to increase the immunogenicity of recombinant H7 hemagglutinin. Published by Elsevier Inc.

引用

页码：55 / 58

页数：4

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