Chemokines as mediators of tumor angiogenesis and neovascularization

被引：100

作者：

Keeley, Ellen C. ^{[1
]}

Mehrad, Borna ^{[2
]}

Strieter, Robert M. ^{[2
]}

机构：

[1] Univ Virginia, Dept Med, Div Cardiol, Charlottesville, VA 22908 USA

[2] Univ Virginia, Dept Med Pulm & Crit Care Med, Charlottesville, VA 22908 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2011年 / 317卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Chemokines; Angiogenesis; Cancer; CELL LUNG-CANCER; HUMAN ENDOTHELIAL-CELLS; LIGAND BIOLOGICAL AXIS; PLATELET FACTOR-IV; NONSMALL CELL; IN-VIVO; CXC CHEMOKINES; PROSTATE-CANCER; GROWTH-FACTOR; BONE-MARROW;

D O I：

10.1016/j.yexcr.2010.10.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemokines are a superfamily of structurally homologous heparin-binding proteins that influence tumor growth and metastasis. Several members of the CXC and CC chemokine families are potent inducers of neovascularization, whereas a subset of the CXC chemokines are potent inhibitors. In this paper, we review the current literature regarding the role of chemokines as mediators of tumor angiogenesis and neovascularization. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：685 / 690

页数：6

共 78 条

[1] The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity [J].

Addison, CL ;

Daniel, TO ;

Burdick, MD ;

Liu, H ;

Ehlert, JE ;

Xue, YY ;

Buechi, L ;

Walz, A ;

Richmond, A ;

Strieter, RM .

JOURNAL OF IMMUNOLOGY, 2000, 165 (09) :5269-5277

[2] Overexpression of the duffy antigen receptor for chemokines (DARC) by NSCLC tumor cells results in increased tumor necrosis [J].

Addison, CL ;

Belperio, JA ;

Burdick, MD ;

Strieter, RM .

BMC CANCER, 2004, 4 (1)

[3] Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases [J].

Arenberg, DA ;

Kunkel, SL ;

Polverini, PJ ;

Morris, SB ;

Burdick, MD ;

Glass, MC ;

Taub, DT ;

Iannettoni, MD ;

Whyte, TI ;

Strieter, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (03) :981-992

[4] Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice [J].

Arenberg, DA ;

Kunkel, SL ;

Polverini, PJ ;

Glass, M ;

Burdick, MD ;

Strieter, RM .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (12) :2792-2802

[5] Improved survival in tumor-bearing SCID mice treated with interferon-γ-inducible protein 10 (IP-10/CXCL10) [J].

Arenberg, DA ;

White, ES ;

Burdick, MD ;

Strom, SRB ;

Strieter, RM .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2001, 50 (10) :533-538

[6] Chemokine/chemokine receptor nomenclature [J].

Bacon, K ;

Baggiolini, M ;

Broxmeyer, H ;

Horuk, R ;

Lindley, I ;

Mantovani, A ;

Matsushima, K ;

Murphy, P ;

Nomiyama, H ;

Oppenheim, J ;

Rot, A ;

Schall, T ;

Tsang, M ;

Thorpe, R ;

Van Damme, J ;

Wadhwa, M ;

Yoshie, O ;

Zlotnik, A ;

Zoon, K .

CYTOKINE, 2003, 21 (01) :48-49

[7] Production and in vivo effects of chemokines CXCL1-3/KC and CCL2/JE in a model of inflammatory angiogenesis in mice [J].

Barcelos, LS ;

Talvani, A ;

Teixeira, AS ;

Cassali, GD ;

Andrade, SP ;

Teixeira, MM .

INFLAMMATION RESEARCH, 2004, 53 (10) :576-584

[8] Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice [J].

Beider, K ;

Nagler, A ;

Wald, O ;

Franitza, S ;

Dagan-Berger, M ;

Wald, H ;

Giladi, H ;

Brocke, S ;

Hanna, J ;

Mandelboim, O ;

Darash-Yahana, M ;

Galun, E ;

Peled, A .

BLOOD, 2003, 102 (06) :1951-1958

[9] Platelet factor 4: An inhibitor of angiogenesis [J].

Bikfalvi, A .

SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2004, 30 (03) :379-385

[10]

Bikfalvi A, 2004, SEMIN THROMB HEMOST, V30, P137

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