Structural and functional cortical abnormalities after upper limb amputation during childhood

被引：41
作者：
Hamzei, F
Liepert, J
Dettmers, C
Adler, T
Kiebel, S
Rijntjes, M
Weiller, C
机构：
[1] Inst Neurol Rehabil, D-20535 Hamburg, Germany
[2] Univ Jena, Dept Neurol, D-6900 Jena, Germany
[3] Univ Klinikum Hamburg Eppendorf, Dept Neurol, Hamburg, Germany
[4] Moritz Klin, Dept Orthoped, Bad Klosterlausnitz, Germany
[5] Wellcome Dept Cognit Neurol, London, England
来源：
NEUROREPORT | 2001年 / 12卷 / 05期
关键词：
amputation; MRI; functional abnormalities; motor system; neuroplasticity; reorganization; structural abnormalities; TMS;
D O I：
10.1097/00001756-200104170-00019
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Functional reorganization has been well documented in the human adult brain after amputation of the arm. To assess the effects of amputation on the developing brain, we investigated six patients with upper limb amputation in early childhood and one with right dysmelia. Transcranial magnetic stimulation indicated contralateral cortical disinhibition and enlargement of the excitable area of the stump. FMRI data corroborated these plastic changes and also showed an ipsilateral functional reorganization. In the T1-weighted MRI, we found structural deformities of the contralateral and ipsilateral central sulcus in three patients and a contralateral atrophic parietal lobule in two patients. Therefore, arm amputation in childhood affects functional organization as well as anatomical structure in both hemispheres. NeuroReport 12:957-962 (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码：957 / 962
页数：6
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