A New Twist in Cellular Resistance to the Anticancer Drug Bleomycin-A5

被引：15

作者：

Aouida, Mustapha ^{[1
]}

Ramotar, Dindial ^{[1
]}

机构：

[1] Univ Montreal, Hop Maison Neuve Rosemont, Res Ctr, Montreal, PQ H1T 2M4, Canada

来源：

CURRENT DRUG METABOLISM | 2010年 / 11卷 / 07期

基金：

加拿大健康研究院;

关键词：

Bleomycin; cancer cells; drug resistance; substrates; therapy; transport; MEMBRANE CARNITINE TRANSPORTER; ORGANIC CATION TRANSPORTERS; GENOME-WIDE SCREEN; SACCHAROMYCES-CEREVISIAE; MAMMALIAN-CELLS; IDENTIFICATION; YEAST; HYDROLASE; CARCINOMA; CLEAVAGE;

D O I：

10.2174/138920010792927307

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bleomycin is a potent chemotherapeutic agent that can mediate cell killing by attacking the DNA. It is used in combination with other antineoplastic agents to effectively treat lymphomas, testicular carcinomas and squamous cell carcinomas of the cervix, head and neck. However, resistance to bleomycin remains a persistent limitation in exploiting the full therapeutic benefit of the drug for other types of cancers. Herein, we review recent findings from both yeast and human cells showing that uptake of bleomycin-A5 is a key mechanism that limits toxicity of the drug. We also discuss how the mammalian transporter hCT2 (SLC22A16) could be used to predict the outcome of tumor responses towards bleomycin therapy, and highlight the importance of further exploring this permease with respect to its regulation and pharmacological substrates for treating a wide range of cancers.

引用

页码：595 / 602

页数：8

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