The molecular pathogenesis of Ewing sarcoma

被引：45

作者：

Mackintosh, Carlos ^{[2
]}

Madoz-Gurpide, Juan ^{[3
]}

Luis Ordonez, Jose ^{[2
]}

Osuna, Daniel ^{[4
]}

Herrero-Martin, David ^{[1
]}

机构：

[1] Univ Childrens Hosp, Dept Oncol, Zurich, Switzerland

[2] Univ Salamanca, CSIC, Lab Mol Pathol Sarcomas, Ctr Invest Canc,Inst Biol Mol & Celular Canc, E-37008 Salamanca, Spain

[3] Fdn Jimenez Diaz, Grp Canc Res, E-28040 Madrid, Spain

[4] Univ Salamanca, Fac Biol, Dept Fisiol Vegetal CIALE, Villamayor, Salamanca, Spain

来源：

CANCER BIOLOGY & THERAPY | 2010年 / 9卷 / 09期

关键词：

Ewing sarcoma; EWS-ETS; pediatric; molecular targets; signaling pathways; mouse models; novel therapies; FACTOR-I-RECEPTOR; COMPARATIVE GENOMIC HYBRIDIZATION; PRECLINICAL TESTING PROGRAM; STEM-CELL TRANSPLANTATION; PROTEASOME INHIBITOR BORTEZOMIB; ENDOTHELIAL GROWTH-FACTOR; PEDIATRIC SOLID TUMORS; RNA-BINDING PROTEIN; ETS FUSION PROTEINS; GENE-EXPRESSION;

D O I：

10.4161/cbt.9.9.11511

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ewing sarcoma family tumors (ESFT) are a group of aggressive solid bone and soft tissue malignancies of children and young adults characterized by specific chromosomal translocations that give rise to EWS-ETS aberrant transcription factors. Identification of EWS-ETS target genes and their role in tumor signaling networks together with the unravelling of the cell of origin will facilitate the translation into new treatment modalities for these neoplasms.

引用

页码：655 / 667

页数：13

共 208 条

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