Glial cell line-derived neurotrophic factor protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice

被引：34

作者：

Cheng, FC

Ni, DR

Wu, MC

Kuo, JS

Chia, LG ^{[1
]}

机构：

[1] Taichung Vet Gen Hosp, Neurol Sect, Taichung 40705, Taiwan

[2] Taichung Vet Gen Hosp, Dept Med Res, Taichung 40705, Taiwan

[3] Univ N Texas, Dept Biochem, Ft Worth, TX 76107 USA

来源：

NEUROSCIENCE LETTERS | 1998年 / 252卷 / 02期

关键词：

glial cell line-derived neurotrophic factor; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Parkinson's disease;

D O I：

10.1016/S0304-3940(98)00554-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To mimic chronic exposure to neurotoxins in inducing dopaminergic cell damage, multiple doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were injected in C57BL/6 mice. Effects of pre- and post-treatment with the glial cell line-derived neurotrophic factor (GDNF) by injections into the striatum were investigated. GDNF exerts protective and reverse effects on the dopaminergic damage, supporting the potential application of GDNF in prevention and treatment of Parkinson's disease. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved

引用

页码：87 / 90

页数：4

共 18 条

[1] POSTMORTEM DISTRIBUTION OF DOPAMINE AND HOMOVANILLIC-ACID IN HUMAN-BRAIN, VARIATIONS RELATED TO AGE, AND A REVIEW OF THE LITERATURE [J].