World Health Organization 2016 Classification of Central Nervous System Tumors

被引：63

作者：

Diamandis, Phedias ^{[1
]}

Aldape, Kenneth ^{[1
]}

机构：

[1] Princess Margaret Canc Ctr, MacFeeters Hamilton Ctr Neurooncol Res, 101 Coll St,14-601, Toronto, ON M5G 1L7, Canada

来源：

NEUROLOGIC CLINICS | 2018年 / 36卷 / 03期

关键词：

World Health Organization; Brain tumors; Neuropathology; Classification; Molecular pathology; OLIGODENDROGLIOMA; FUSIONS; ASTROCYTOMA; SUBGROUPS; DIAGNOSIS; GLIOMA;

D O I：

10.1016/j.ncl.2018.04.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The recent update of the World Health Organization (WHO) classification of tumors of the central nervous system represents a paradigm shift. Previous iterations of the classification relied on morphologic features for classification. In the 2016 update, the definitions of specific neoplastic entities tumors now include precise molecularly defined entities. This article discusses this paradigm shift and focuses on the refinements in classification criteria, relations to previous editions, and their implication to neuropathology and neuro-oncology practice. The authors distinguish the criteria that were used to determine why molecular changes were included.

引用

页码：439 / +

页数：10

共 25 条

[1]

Aldape K, 2016, NEURO-ONCOLOGY, V19

[2] Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas [J].

Brat, Daniel J. ;

Verhaak, Roel G. W. ;

Al-dape, Kenneth D. ;

Yung, W. K. Alfred ;

Salama, Sofie R. ;

Cooper, Lee A. D. ;

Rheinbay, Esther ;

Miller, C. Ryan ;

Vitucci, Mark ;

Morozova, Olena ;

Robertson, A. Gordon ;

Noushmehr, Houtan ;

Laird, Peter W. ;

Cherniack, Andrew D. ;

Akbani, Rehan ;

Huse, Jason T. ;

Ciriello, Giovanni ;

Poisson, Laila M. ;

Barnholtz-Sloan, Jill S. ;

Berger, Mitchel S. ;

Brennan, Cameron ;

Colen, Rivka R. ;

Colman, Howard ;

Flanders, Adam E. ;

Giannini, Caterina ;

Grifford, Mia ;

Iavarone, Antonio ;

Jain, Rajan ;

Joseph, Isaac ;

Kim, Jaegil ;

Kasaian, Katayoon ;

Mikkelsen, Tom ;

Murray, Bradley A. ;

O'Neill, Brian Patrick ;

Pachter, Lior ;

Parsons, Donald W. ;

Sougnez, Carrie ;

Sulman, Erik P. ;

Vandenberg, Scott R. ;

Van Meir, Erwin G. ;

von Deimling, Andreas ;

Zhang, Hailei ;

Crain, Daniel ;

Lau, Kevin ;

Mallery, David ;

Morris, Scott ;

Paulauskis, Joseph ;

Penny, Robert ;

Shelton, Troy ;

Sherman, Mark .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (26) :2481-2498

[3] Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors [J].

Chmielecki, Juliann ;

Crago, Aimee M. ;

Rosenberg, Mara ;

O'Connor, Rachael ;

Walker, Sarah R. ;

Ambrogio, Lauren ;

Auclair, Daniel ;

McKenna, Aaron ;

Heinrich, Michael C. ;

Frank, David A. ;

Meyerson, Matthew .

NATURE GENETICS, 2013, 45 (02) :131-132

[4] Insights From Molecular Profiling of Adult Glioma [J].

Diamandis, Phedias ;

Aldape, Kenneth D. .

JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (21) :2386-+

[5] Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma [J].

Diamandis, Phedias ;

Ferrer-Luna, Ruben ;

Huang, Raymond Y. ;

Folkerth, Rebecca D. ;

Ligon, Azra H. ;

Wen, Patrick Y. ;

Beroukhim, Rameen ;

Ligon, Keith L. ;

Ramkissoon, Shakti H. .

DIAGNOSTIC PATHOLOGY, 2016, 11

[6] K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas [J].

Dong-Anh Khuong-Quang ;

Buczkowicz, Pawel ;

Rakopoulos, Patricia ;

Liu, Xiao-Yang ;

Fontebasso, Adam M. ;

Bouffet, Eric ;

Bartels, Ute ;

Albrecht, Steffen ;

Schwartzentruber, Jeremy ;

Letourneau, Louis ;

Bourgey, Mathieu ;

Bourque, Guillaume ;

Montpetit, Alexandre ;

Bourret, Genevieve ;

Lepage, Pierre ;

Fleming, Adam ;

Lichter, Peter ;

Kool, Marcel ;

von Deimling, Andreas ;

Sturm, Dominik ;

Korshunov, Andrey ;

Faury, Damien ;

Jones, David T. ;

Majewski, Jacek ;

Pfister, Stefan M. ;

Jabado, Nada ;

Hawkins, Cynthia .

ACTA NEUROPATHOLOGICA, 2012, 124 (03) :439-447

[7] Oligodendrogliomas: Reproducibility and prognostic value of histologic diagnosis and grading [J].

Giannini, C ;

Scheithauer, BW ;

Weaver, AL ;

Burger, PC ;

Kros, JM ;

Mork, S ;

Graeber, MB ;

Bauserman, S ;

Buckner, JC ;

Burton, J ;

Riepe, R ;

Tazelaar, HD ;

Nascimento, AG ;

Crotty, T ;

Keeney, GL ;

Pernicone, P ;

Altermatt, H .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2001, 60 (03) :248-262

[8] Mixed glioma with molecular features of composite oligodendroglioma and astrocytoma: a true "oligoastrocytoma"? [J].

Huse, Jason T. ;

Diamond, Eli L. ;

Wang, Lu ;

Rosenblum, Marc K. .

ACTA NEUROPATHOLOGICA, 2015, 129 (01) :151-153

[9] Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes [J].

Labussiere, Marianne ;

Boisselier, Blandine ;

Mokhtari, Karima ;

Di Stefano, Anna-Luisa ;

Rahimian, Anais ;

Rossetto, Marta ;

Ciccarino, Pietro ;

Saulnier, Olivier ;

Paterra, Rosina ;

Marie, Yannick ;

Finocchiaro, Gaetano ;

Sanson, Marc .

NEUROLOGY, 2014, 83 (13) :1200-1206

[10] The 2007 WHO classification of tumours of the central nervous system (vol 114, pg 97, 2007) [J].

Louis, David N. ;

Ohgaki, Hiroko ;

Wiestler, Otmar D. ;

Cavenee, Webster K. ;

Burger, Peter C. ;

Jouvet, Anne ;

Scheithauer, Bernd W. ;

Kleihues, Paul .

ACTA NEUROPATHOLOGICA, 2007, 114 (05) :547-547

← 1 2 3 →