An Overview of Drug Resistance in Protozoal Diseases

被引：122
作者：
Capela, Rita [1 ]
Moreira, Rui [1 ]
Lopes, Francisca [1 ]
机构：
[1] Univ Lisbon, Fac Farm, Inst Invest Medicamento iMed ULisboa, Ave Prof Gama Pinto, P-1649003 Lisbon, Portugal
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 22期
关键词：
protozoan; drug resistance; malaria; leishmaniasis; trypanosomiasis; AMPHOTERICIN-B RESISTANCE; LEISHMANIA-DONOVANI; PENTAMIDINE SUSCEPTIBILITY; AQUAGLYCEROPORIN; CROSS-RESISTANCE; MOLECULAR-BASIS; AFRICAN; PAROMOMYCIN; MILTEFOSINE; MECHANISMS;
D O I：
10.3390/ijms20225748
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Protozoan diseases continue to be a worldwide social and economic health problem. Increased drug resistance, emerging cross resistance, and lack of new drugs with novel mechanisms of action significantly reduce the effectiveness of current antiprotozoal therapies. While drug resistance associated to anti-infective agents is a reality, society seems to remain unaware of its proportions and consequences. Parasites usually develops ingenious and innovative mechanisms to achieve drug resistance, which requires more research and investment to fight it. In this review, drug resistance developed by protozoan parasites Plasmodium, Leishmania, and Trypanosoma will be discussed.
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页数：30
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