Skin Autofluorescence is an Independent Predictor of Post Stroke Infection in Diabetes

被引：2
|
作者：
Filipov, Alexandra [1 ]
Fuchshuber, Heike [1 ]
Kraus, Josephine [1 ]
Ebert, Anne D. [1 ]
Sandikci, Vesile [1 ]
Alonso, Angelika [1 ]
机构：
[1] Heidelberg Univ, Univ Med Mannheim, Dept Neurol, Heidelberg, Germany
来源：
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | 2021年 / 30卷 / 09期
关键词：
Diabetes mellitus; Hyperglycemia; Skin autofluorescence; Acute stroke; Post stroke infection; ACUTE ISCHEMIC-STROKE; IMMUNE; RECEPTOR; RAGE;
D O I：
10.1016/j.jstrokecerebrovasdis.2021.105949
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Post stroke infection occurs in 15-20% of acute stroke patients and is associated with a poor longterm outcome. In a prospective study on 113 acute ischemic stroke patients with diabetes mellitus 15.9% suffered nosocomial infection. We found chronic hyperglycemia measured by skin autofluorescence in arbitrary units to be an independent predictor of a nosocomial infection post stroke (OR = 3.24 [CI 95%: 1.13; 9.26], p = 0.029). Skin autofluorescence represents the glycemic memory beyond HbA1c. Potential mechanisms leading from increased skin autofluorescence to vulnerability for infectious complications include more severe strokes due to preexisting vasculopathy and exacerbated post stroke immunosuppression.
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页数：5
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