Introduction to systematic reviews and meta-analysis

被引：59
作者：
McKenzie, Joanne E. [1 ]
Beller, Elaine M. [3 ]
Forbes, Andrew B. [1 ,2 ]
机构：
[1] Monash Univ, Sch Publ Hlth & Prevent Med, 549 St Kilda Rd, Melbourne, Vic 3004, Australia
[2] Victorian Ctr Biostat ViCBiostat, Melbourne, Vic, Australia
[3] Bond Univ, Ctr Res Evidence Based Practice, Gold Coast, Qld, Australia
来源：
RESPIROLOGY | 2016年 / 21卷 / 04期
基金：
英国医学研究理事会;
关键词：
fixed effect model; meta-analysis; random effects model; systematic review; tutorial; RANDOM-EFFECTS MODELS; CLINICAL-TRIALS; COCHRANE-DATABASE; HETEROGENEITY; QUALITY; BIAS; PUBLICATION; OUTCOMES;
D O I：
10.1111/resp.12783
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Systematic reviews provide a method for collating and synthesizing research, and are used to inform healthcare decision making by clinicians, consumers and policy makers. A core component of many systematic reviews is a meta-analysis, which is a statistical synthesis of results across studies. In this review article, we introduce meta-analysis, focusing on the different meta-analysis models, their interpretation, how a model should be selected and discuss potential threats to the validity of meta-analyses. We illustrate the application of meta-analysis using data from a review examining the effects of early use of inhaled corticosteroids in the emergency department treatment of acute asthma.
引用
收藏
页码：626 / 637
页数：12
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