Pharmacology of Store-operated Calcium Channels

被引：104

作者：

Putney, James W. ^{[1
]}

机构：

[1] NIEHS, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA

来源：

MOLECULAR INTERVENTIONS | 2010年 / 10卷 / 04期

基金：

美国国家卫生研究院;

关键词：

ACTIVATED CA2+ CHANNELS; 2-AMINOETHOXYDIPHENYL BORATE 2-APB; SEVERE COMBINED IMMUNODEFICIENCY; INOSITOL TRISPHOSPHATE RECEPTOR; CRAC CHANNELS; PLASMA-MEMBRANE; CATION CHANNELS; TRPC CHANNELS; T-LYMPHOCYTES; CA2+-DEPENDENT INACTIVATION;

D O I：

10.1124/mi.10.4.4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Store-operated calcium entry is a process by which the depletion of calcium from the endoplasmic reticulum activates calcium influx across the plasma membrane. In the past few years, the major players in this pathway have been identified. STIM1 and STIM2 function as calcium sensors in the endoplasmic reticulum and can interact with and activate plasma membrane channels comprised of Orai1, Orai2, or Orai3 subunits. This review discusses recent advances in our understanding of this widespread signaling mechanism as well as the mechanisms by which a number of interesting pharmacological agents modify it.

引用

页码：209 / 218

页数：10

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