Direct synthesis of amides from nonactivated carboxylic acids using urea as nitrogen source and Mg(NO3)2or imidazole as catalysts

被引：32

作者：

Chhatwal, A. Rosie ^{[1
]}

Lomax, Helen, V ^{[2
]}

Blacker, B. A. John ^{[3
]}

Williams, Jonathan M. J. ^{[1
]}

Marce, Patricia ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] Univ Bath, Ctr Sustainable Chem Technol, Bath BA2 7AY, Avon, England

[3] Univ Leeds, Sch Chem, Inst Proc Res & Dev, Woodhouse Lane, Leeds LS2 9JT, W Yorkshire, England

来源：

CHEMICAL SCIENCE | 2020年 / 11卷 / 22期

基金：

英国工程与自然科学研究理事会;

关键词：

PEPTIDE COUPLING REAGENTS; ONE-POT SYNTHESIS; OXIDATIVE AMIDATION; HIGHLY EFFICIENT; ENZYMATIC-SYNTHESIS; AQUEOUS-MEDIUM; BOND FORMATION; AMINES; ALDEHYDES; ALCOHOLS;

D O I：

10.1039/d0sc01317j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new method for the direct synthesis of primary and secondary amides from carboxylic acids is described using Mg(NO3)(2)center dot 6H(2)O or imidazole as a low-cost and readily available catalyst, and urea as a stable, and easy to manipulate nitrogen source. This methodology is particularly useful for the direct synthesis of primary and methyl amides avoiding the use of ammonia and methylamine gas which can be tedious to manipulate. Furthermore, the transformation does not require the employment of coupling or activating agents which are commonly required.

引用

页码：5808 / 5818

页数：11

共 117 条

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