Biodegradable polylactide/hydroxyapatite nanocomposite foam scaffolds for bone tissue engineering applications

被引:39
|
作者
Delabarde, Claire [1 ]
Plummer, Christopher J. G. [1 ]
Bourban, Pierre-Etienne [1 ]
Manson, Jan-Anders E. [1 ]
机构
[1] Ecole Polytech Fed Lausanne, Lab Technol Composites & Polymeres LTC, Stn 12, CH-1015 Lausanne, Switzerland
关键词
SUPERCRITICAL CARBON-DIOXIDE; IN-VIVO; POLY(LACTIC ACID); POLYPROPYLENE/CLAY NANOCOMPOSITES; CRYSTALLIZATION KINETICS; BIORESORBABLE COMPOSITES; MECHANICAL-PROPERTIES; CELLULAR STRUCTURE; CO2; DEGRADATION;
D O I
10.1007/s10856-012-4619-1
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Supercritical carbon dioxide processing of poly--lactide (PLLA)/hydroxyapatite (nHA) nanocomposites was investigated as a means to prepare foams suitable as scaffolds in bone tissue engineering applications. For given foaming parameters, addition of nHA to the PLLA gave reduced cell sizes and improved homogeneity in the size distribution, but did not significantly affect the degree of crystallinity, which remained of the order of 50 wt% in all the foams. The compressive modulus and strength were primarily influenced by the porosity and there was no significant reinforcement of the matrix by the nHA. The mechanical properties of the foams were nevertheless comparable with those of trabecular bone, and by adjusting the saturation pressure and depressurization rate it was possible to generate porosities of about 85 %, an interconnected morphology and cell diameters in the range 200-400 mu m from PLLA containing 4.17 vol% nHA, satisfying established geometrical requirements for bone replacement scaffolds.
引用
收藏
页码:1371 / 1385
页数:15
相关论文
共 50 条
  • [1] Fabrication of Polylactide-Based Biodegradable Thermoset Scaffolds for Tissue Engineering Applications
    Sakai, Reika
    John, Baiju
    Okamoto, Masami
    Seppala, Jukka V.
    Vaithilingam, Jayasheelan
    Hussein, Husnah
    Goodridge, Ruth
    MACROMOLECULAR MATERIALS AND ENGINEERING, 2013, 298 (01) : 45 - 52
  • [2] High-Performance Hydroxyapatite Scaffolds for Bone Tissue Engineering Applications
    Gervaso, Francesca
    Scalera, Francesca
    Padmanabhan, Sanosh Kunjalukkal
    Sannino, Alessandro
    Licciulli, Antonio
    INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, 2012, 9 (03) : 507 - 516
  • [3] Hardystonite-diopside nanocomposite scaffolds for bone tissue engineering applications
    Sadeghzade, Sorour
    Emadi, Rahmatollah
    Labbaf, Sheyda
    MATERIALS CHEMISTRY AND PHYSICS, 2017, 202 : 95 - 103
  • [4] Chitosan-hydroxyapatite-MWCNTs nanocomposite patch for bone tissue engineering applications
    Sanchez, Alejandro Gomez
    Prokhorov, Evgen
    Luna-Barcenas, Gabriel
    Doval, R. Roman
    Mendoza, S.
    Rojas-Chavez, H.
    Vargas, Julia Hernandez
    MATERIALS TODAY COMMUNICATIONS, 2021, 28
  • [5] Biodegradable polyphosphazene - hydroxyapatite composites for bone tissue engineering
    Subash, Alsha
    Basanth, Abina
    Kandasubramanian, Balasubramanian
    INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2023, 72 (14) : 1093 - 1111
  • [6] Biodegradable Bone Regeneration Synthetic Scaffolds: in Tissue Engineering
    Hammouche, Salah
    Hammouche, Dalia
    McNicholas, Michael
    CURRENT STEM CELL RESEARCH & THERAPY, 2012, 7 (02) : 134 - 142
  • [7] Sterilization techniques for biodegradable scaffolds in tissue engineering applications
    Dai, Zheng
    Ronholm, Jennifer
    Tian, Yiping
    Sethi, Benu
    Cao, Xudong
    JOURNAL OF TISSUE ENGINEERING, 2016, 7
  • [8] Development of biodegradable polyurethane and bioactive glass nanoparticles scaffolds for bone tissue engineering applications
    Rocha de Oliveira, Agda Aline
    de Carvalho, Sandhra Maria
    Leite, Maria de Fatima
    Orefice, Rodrigo Lambert
    Pereira, Marivalda de Magalhaes
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2012, 100B (05) : 1387 - 1396
  • [9] Nano-hydroxyapatite/β-CD/chitosan nanocomposite for potential applications in bone tissue engineering
    Shakir, Mohammad
    Jolly, Reshma
    Khan, Mohd Shoeb
    Rauf, Ahmar
    Kazmi, Shadab
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016, 93 : 276 - 289
  • [10] Evaluation of mechanical and biocompatibility properties of hydroxyapatite/manganese dioxide nanocomposite scaffolds for bone tissue engineering application
    Azizi, Fatemeh
    Heidari, Fatemeh
    Fahimipour, Farahnaz
    Sajjadnejad, Mohammad
    Vashaee, Daryoosh
    Tayebi, Lobat
    INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, 2020, 17 (05) : 2439 - 2449