First isolation of Tropheryma whipplei from bronchoalveolar fluid and clinical implications

被引:44
作者
Fenollar, Florence [1 ]
Ponge, Thierry [2 ]
La Scola, Bernard [1 ]
Lagier, Jean-Christophe [1 ]
Lefebvre, Maeva [2 ]
Raoult, Didier [1 ]
机构
[1] Univ Aix Marseille 2, Fac Med, IFR 48, URMITE,CNRS,UMR 6236,IRD 198, F-13385 Marseille 05, France
[2] CHU Nantes, Serv Med Interne, Nantes, France
关键词
Whipple's disease; Tropheryma whipplei; Bronchoalveolar fluid; Pneumonia; DISEASE; BACTEREMIA; CULTURE; SALIVA; STOOL;
D O I
10.1016/j.jinf.2011.11.026
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
A patient presented diffuse pulmonary parenchymal micronodules. Tropheryma whipplei was detected in the saliva, a bronchial biopsy and bronchoalveolar fluid. PAS staining, immunohistochemistry and PCR for T. whipplei were negative in the duodenal biopsies. T. whipplei was isolated from the bronchoalveolar fluid, reinforcing its role as a respiratory pathogen. (C) 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:275 / 278
页数:4
相关论文
共 14 条
[1]   An Experimental Mouse Model to Establish Tropheryma whipplei as a Diarrheal Agent [J].
Al Moussawi, Khatoun ;
Malou, Nada ;
Mege, Jean-Louis ;
Raoult, Didier ;
Desnues, Benoit .
JOURNAL OF INFECTIOUS DISEASES, 2011, 204 (01) :44-50
[2]   Tropheryma whipplei in Patients with Pneumonia [J].
Bousbia, Sabri ;
Papazian, Laurent ;
Auffray, Jean-Pierre ;
Fenollar, Florence ;
Martin, Claude ;
Li, Wenjun ;
Chiche, Laurent ;
La Scola, Bernard ;
Raoult, Didier .
EMERGING INFECTIOUS DISEASES, 2010, 16 (02) :258-263
[3]   Culture of Tropheryma whipplei from human samples:: A 3-year experience (1999 to 2002) [J].
Fenollar, F ;
Birg, ML ;
Gauduchon, V ;
Raoult, D .
JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (08) :3816-3822
[4]   Value of Tropheryma whipplei quantitative polymerase chain reaction assay for the diagnosis of Whipple disease:: Usefulness of saliva and stool specimens for first-line screening [J].
Fenollar, Florence ;
Laouira, Sonia ;
Lepidi, Hubert ;
Rolain, Jean-Marc ;
Raoult, Didier .
CLINICAL INFECTIOUS DISEASES, 2008, 47 (05) :659-667
[5]   Prevalence of asymptomatic Tropheryma whipplei carriage among humans and nonhuman primates [J].
Fenollar, Florence ;
Trani, Michele ;
Davoust, Bernard ;
Salle, Bettina ;
Birg, Marie-Laure ;
Rolain, Jean-Marc ;
Raoult, Didier .
JOURNAL OF INFECTIOUS DISEASES, 2008, 197 (06) :880-887
[6]   Tropheryma whipplei Bacteremia during Fever in Rural West Africa [J].
Fenollar, Florence ;
Mediannikov, Oleg ;
Socolovschi, Cristina ;
Bassene, Hubert ;
Diatta, Georges ;
Richet, Herve ;
Tall, Adama ;
Sokhna, Cheikh ;
Trape, Jean-Francois ;
Raoult, Didier .
CLINICAL INFECTIOUS DISEASES, 2010, 51 (05) :515-521
[7]   A Paradoxical Tropheryma whipplei Western Blot Differentiates Patients with Whipple Disease from Asymptomatic Carriers [J].
Fenollar, Florence ;
Amphoux, Bernard ;
Raoult, Didier .
CLINICAL INFECTIOUS DISEASES, 2009, 49 (05) :717-723
[8]   Medical progress - Whipple's disease [J].
Fenollar, Florence ;
Puechal, Xavier ;
Raoult, Didier .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (01) :55-66
[10]   Molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosis [J].
Harris, J. Kirk ;
De Groote, Mary Ann ;
Sagel, Scott D. ;
Zemanick, Edith T. ;
Kapsner, Robert ;
Penvari, Churee ;
Kaess, Heidi ;
Deterding, Robin R. ;
Accurso, Frank J. ;
Pace, Norman R. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (51) :20529-20533