Cytokines and irritable bowel syndrome: Where do we stand?

被引：56
作者：
Bashashati, Mohammad [1 ,2 ]
Rezaei, Nima [3 ,4 ,5 ]
Andrews, Christopher N. [6 ]
Chen, Chun-Qiu [7 ]
Daryani, Nasser Ebrahimi [8 ]
Sharkey, Keith A. [2 ]
Storr, Martin A. [2 ,9 ]
机构：
[1] Univ Calgary, Hlth Sci Ctr, Gastrointestinal Res Grp, Snyder Inst Infect Immun & Inflammat, Calgary, AB T2N 4N1, Canada
[2] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB T2N 4N1, Canada
[3] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
[4] Univ Tehran Med Sci, Mol Immunol Res Ctr, Tehran, Iran
[5] Univ Tehran Med Sci, Dept Immunol, Sch Med, Tehran, Iran
[6] Univ Calgary, Dept Med, Div Gastroenterol, Calgary, AB T2N 4N1, Canada
[7] Tongji Univ, Shanghai Peoples Hosp 10, Dept Gastrointestinal Surg, Sch Med, Shanghai 200092, Peoples R China
[8] Univ Tehran Med Sci, Dept Gastroenterol & Hepatol, Tehran, Iran
[9] Univ Munich, Munich, Germany
来源：
CYTOKINE | 2012年 / 57卷 / 02期
关键词：
Cytokine; Irritable bowel syndrome; Inflammation; Genetic polymorphism; NECROSIS-FACTOR-ALPHA; FUNCTIONAL GASTROINTESTINAL DISORDERS; NEONATAL MATERNAL SEPARATION; COLONIC EPITHELIAL BARRIER; IL-6 EXCITE NEURONS; NERVOUS-SYSTEM; INTESTINAL DYSMOTILITY; GENE POLYMORPHISMS; MAST-CELLS; INTERLEUKIN-1-BETA;
D O I：
10.1016/j.cyto.2011.11.019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder, which presents with one or more gastrointestinal symptoms without any structural or organic abnormality. The etiology and pathophysiological mechanisms of IBS remain uncertain. Residual or reactivated inflammation at the molecular level is considered the underlying mechanism of post-infectious IBS. On the other hand, genetic variations in the immunological components of the body, including cytokine gene polymorphisms, are proposed as a potential mechanism of IBS even in patients without previous gastrointestinal infection. Several studies have suggested imbalanced cytokine signaling as an etiology for IBS. In this review, recent findings on cytokine profiles and cytokine gene polymorphisms in patients with IBS are described and the role of cytokines in animal models of IBS is discussed. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：201 / 209
页数：9
相关论文
共 83 条
  • [1] Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction
    Akiho, H
    Deng, MK
    Blennerhassett, P
    Kanbayashi, H
    Collins, SM
    [J]. GASTROENTEROLOGY, 2005, 129 (01) : 131 - 141
  • [2] Role of IL-4, IL-13, and STAT6 in inflammation-induced hypercontractility of murine smooth muscle cells
    Akiho, H
    Blennerhassett, P
    Deng, YK
    Collins, SM
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2002, 282 (02): : G226 - G232
  • [3] Mechanism of cytokine modulation of epithelial tight junction barrier
    Al-Sadi, Rana
    Boivin, Michel
    Ma, Thomas
    [J]. FRONTIERS IN BIOSCIENCE-LANDMARK, 2009, 14 : 2765 - 2778
  • [4] Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice
    Annahazi, Anita
    Gecse, Krisztina
    Dabek, Marta
    Ait-Belgnaoui, Afifa
    Rosztoczy, Andras
    Roka, Richard
    Molnar, Tamas
    Theodorou, Vassilia
    Wittmann, Tibor
    Bueno, Lionel
    Eutamene, Helene
    [J]. PAIN, 2009, 144 (1-2) : 209 - 217
  • [5] Postinfectious Irritable Bowel Syndrome
    Barbara, Giovanni
    Cremon, Cesare
    Pallotti, Francesca
    De Giorgio, Roberto
    Stanghellini, Vincenzo
    Corinaldesi, Roberto
    [J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2009, 48 : S95 - S97
  • [6] Barkhordari Elham, 2011, Avicenna Journal of Medical Biotechnology, V3, P45
  • [7] T-Helper 1, T-Helper 2, and T-Regulatory Cytokines Gene Polymorphisms in Irritable Bowel Syndrome
    Barkhordari, Elham
    Rezaei, Nima
    Mahmoudi, Mahdi
    Larki, Pegah
    Ahmadi-Ashtiani, Hamid Reza
    Ansaripour, Bita
    Alighardashi, Maryam
    Bashashati, Mohammad
    Amirzargar, Ali Akbar
    Ebrahimi-Daryani, Naser
    [J]. INFLAMMATION, 2010, 33 (05) : 281 - 286
  • [8] Proinflammatory Cytokine Gene Polymorphisms in Irritable Bowel Syndrome
    Barkhordari, Elham
    Rezaei, Nima
    Ansaripour, Bita
    Larki, Pegah
    Alighardashi, Maryam
    Ahmadi-Ashtiani, Hamid Reza
    Mahmoudi, Mahdi
    Keramati, Mohammad-Reza
    Habibollahi, Peiman
    Bashashati, Mohammad
    Ebrahimi-Daryani, Naser
    Amirzargar, Ali Akbar
    [J]. JOURNAL OF CLINICAL IMMUNOLOGY, 2010, 30 (01) : 74 - 79
  • [9] Neonatal maternal deprivation triggers long term alterations in colonic epithelial barrier and mucosal immunity in rats
    Barreau, F
    Ferrier, L
    Fioramonti, J
    Bueno, L
    [J]. GUT, 2004, 53 (04) : 501 - 506
  • [10] Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice
    Bashashati, M.
    Storr, M. A.
    Nikas, S. P.
    Wood, J. T.
    Godlewski, G.
    Liu, J.
    Ho, W.
    Keenan, C. M.
    Zhang, H.
    Alapafuja, S. O.
    Cravatt, B. F.
    Lutz, B.
    Mackie, K.
    Kunos, G.
    Patel, K. D.
    Makriyannis, A.
    Davison, J. S.
    Sharkey, K. A.
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2012, 165 (05) : 1556 - 1571
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