Biotransformation of Bioactive Isocaryolanes by Botrytis cinerea

被引：14

作者：

Ascari, Jociani ^{[2
]}

Diamantino Boaventura, Maria Amelia ^{[2
]}

Takahashi, Jacqueline Aparecida ^{[2
]}

Duran-Patron, Rosa ^{[1
]}

Hernandez-Galan, Rosario ^{[1
]}

Macias-Sanchez, Antonio J. ^{[1
]}

Collado, Isidro G. ^{[1
]}

机构：

[1] Univ Cadiz, Fac Ciencias, Dept Quim Organ, Puerto Real 11510, Spain

[2] Univ Fed Minas Gerais, Inst Ciencias Exatas, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 08期

关键词：

MITSUNOBU CONDITIONS; CARYOPHYLLENE OXIDE; ANTIFUNGAL ACTIVITY; METABOLITES; INHIBITION; SESQUITERPENOIDS; REARRANGEMENT; PATCHOULOL; GINSENOL; CULTURE;

D O I：

10.1021/np1009465

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The metabolism of the fungistatic agent (8R,9R)-8-methoxyisocaryolan-9-ol (4) by the fungus Botrytis cinerea has been investigated. Biotransformation of compound 4 yielded compounds 5 and 6-9. No dihydrobotrydial is observed after 4 days of incubation of compound 4. Separate biotransformation of (8R,9R)-isocaryolane-8,9-diol (5) yielded compounds 7-11. The evaluation of the fungistatic activity against B. cinerea of compounds 4, 5, and 6 is reported. (4R,8R,9R)-8-Methoxyisocaryolane-9,15-diol (6), a major metabolite of (8R,9R)-8-methoxyisocaryolan-9-ol (4), shows a much reduced biological activity when compared with the parent compound. Isocaryolane derivatives 6-11 are described for the first time.

引用

页码：1707 / 1712

页数：6

共 31 条

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