One-step syntheses of nitrofuranyl benzimidazoles that are active against multidrug-resistant bacteria

被引：11
作者：
Moraski, Garrett C. [1 ]
Thanassi, Jane A. [2 ]
Podos, Steven D. [2 ]
Pucci, Michael J. [2 ]
Miller, Marvin J. [1 ]
机构：
[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46656 USA
[2] Achill Pharmaceut, Antimicrobial Drug Discovery, New Haven, CT USA
来源：
JOURNAL OF ANTIBIOTICS | 2011年 / 64卷 / 10期
基金：
美国国家卫生研究院;
关键词：
antibiotic; benzimidazole; MRSA; nitrofuran; VRE; CEPHALOSPORINS;
D O I：
10.1038/ja.2011.67
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Nitrofuranyl benzimidazoles can be made in one synthetic step from commercially available starting materials. The compounds displayed unexpected antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci with MICs as low as 1 mu g ml(-1). The Journal of Antibiotics (2011) 64, 667-671; doi:10.1038/ja.2011.67; published online 3 August 2011
引用
收藏
页码：667 / 671
页数：5
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