Preparation and In Vitro Evaluation of Simvastatin Ethosome

被引：13

作者：

An, Keyao ^{[1
]}

Sun, Yong ^{[1
]}

Xu, Lisa ^{[1
]}

Cui, Xiangzhen ^{[2
]}

机构：

[1] Qingdao Univ, Coll Med, Fac Pharm, Qingdao 266021, Shandong, Peoples R China

[2] Xinshidai Pharmaceut Corp, Ctr Res & Dev, Linyi, Peoples R China

来源：

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY | 2011年 / 39卷 / 06期

关键词：

Ethosome; orthogonal test; encapsulation efficiency; HPLC; TRANSDERMAL DELIVERY; SKIN DELIVERY; LIPOSOMES; PENETRATION; CARRIERS;

D O I：

10.3109/10731199.2011.622281

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

To prepare ethosome loading simvastatin, an orthogonal test was applied to optimize the prescriptions, and the qualities of simvastatin ethosome were characterized by the shape, particle size, encapsulation efficiency (EE), and stability. The formation of 40% (v/v) ethanol, 0.02% (m/v) cholesterol, 2.0% (m/v) soy lecithin, and 5% (m/v) polyoxyethylene hydrogenated castor oil showed the maximal EE (69.3%). We observed the shape of simvastatin ethosome through TEM. The average size of the particles was 52.4 +/- 3.24nm, which was detected by a N5 submicron particle size analyzer. After 120 days storage in 4 degrees C and at room temperature, the simvastatin ethosome had no significant change.

引用

页码：347 / 350

页数：4

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